Integrative Transcriptomics Data Mining to Explore the Functions of <i>TDP1α</i> and <i>TDP1β</i> Genes in the <i>Arabidopsis thaliana</i> Model Plant

Integrative Transcriptomics Data Mining to Explore the Functions of <i>TDP1α</i> and <i>TDP1β</i> Genes in the <i>Arabidopsis thaliana</i> Model Plant

The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA in the DNA–topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small <i>TDP1</i> gene subfamily is present in plants,...

Full description

Bibliographic Details
Main Authors:	Paola Pagano, Andrea Pagano, Stefano Paternolli, Alma Balestrazzi, Anca Macovei
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	Genes
Subjects:	<i>Arabidopsis thaliana</i> DNA damage DNA repair gene expression tyrosyl-DNA phosphodiesterase 1 stress response
Online Access:	https://www.mdpi.com/2073-4425/14/4/884

Similar Items

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining
by: Giacomo Mutti, et al.
Published: (2020-12-01)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
by: Ivan Anticevic, et al.
Published: (2023-10-01)

Ultrastructural and Molecular Analyses Reveal Enhanced Nucleolar Activity in Medicago truncatula Cells Overexpressing the MtTdp2α Gene
by: Anca Macovei, et al.
Published: (2018-05-01)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
by: Nadezhda S. Dyrkheeva, et al.
Published: (2022-04-01)

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
by: Irina A. Chernyshova, et al.
Published: (2022-12-01)

A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors
by: Ann-Katrine Jakobsen, et al.
Published: (2021-07-01)

A Single Amino Acid Substitution in RFC4 Leads to Endoduplication and Compromised Resistance to DNA Damage in <i>Arabidopsis thaliana</i>
by: Kan Cui, et al.
Published: (2022-06-01)

Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway
by: Yutian Zhang, et al.
Published: (2021-08-01)

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
by: Nadezhda S. Dyrkheeva, et al.
Published: (2021-10-01)

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
by: Irina V. Il’ina, et al.
Published: (2020-07-01)

45S rDNA Diversity <i>In Natura</i> as One Step towards Ribosomal Heterogeneity in <i>Arabidopsis thaliana</i>
by: Valérie Delorme-Hinoux, et al.
Published: (2023-07-01)

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties
by: Dmitry I. Ivankin, et al.
Published: (2023-02-01)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
by: Alexandra L. Zakharenko, et al.
Published: (2020-08-01)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
by: Aleksander S. Filimonov, et al.
Published: (2019-10-01)

The Role of Topoisomerase II in DNA Repair and Recombination in <i>Arabidopsis thaliana</i>
by: Marina Martinez-Garcia, et al.
Published: (2021-12-01)

Stochastic Variation in DNA Methylation Modulates Nucleosome Occupancy and Alternative Splicing in <i>Arabidopsis thaliana</i>
by: Ibtissam Jabre, et al.
Published: (2022-04-01)

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
by: Nadezhda S. Dyrkheeva, et al.
Published: (2023-03-01)

<i>Arabidopsis Toxicos en Levadura 12</i> Modulates Salt Stress and ABA Responses in <i>Arabidopsis thaliana</i>
by: Feng Kong, et al.
Published: (2022-06-01)

Genetic Mapping of Genotype-by-Ploidy Effects in <i>Arabidopsis thaliana</i>
by: Cris L. Wijnen, et al.
Published: (2023-05-01)

Phytohormones as Regulators of Mitochondrial Gene Expression in <i>Arabidopsis thaliana</i>
by: Ivan A. Bychkov, et al.
Published: (2023-11-01)

Conserved and Opposite Transcriptome Patterns during Germination in <i>Hordeum vulgare</i> and <i>Arabidopsis thaliana</i>
by: Yanqiao Zhu, et al.
Published: (2020-10-01)

Biochemical Characterization of 13-Lipoxygenases of <i>Arabidopsis thaliana</i>
by: Daniel Maynard, et al.
Published: (2021-09-01)

Key Pathways and Genes of <i>Arabidopsis thaliana</i> and <i>Arabidopsis halleri</i> Roots under Cadmium Stress Responses: Differences and Similarities
by: Gabriella Sferra, et al.
Published: (2023-04-01)

Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level
by: Joanna Proszek, et al.
Published: (2014-01-01)

Long-Chain Polyisoprenoids Are Synthesized by AtCPT1 in <i>Arabidopsis thaliana</i>
by: Przemyslaw Surowiecki, et al.
Published: (2019-07-01)

Nitric Oxide and Globin Glb1 Regulate <i>Fusarium oxysporum</i> Infection of <i>Arabidopsis thaliana</i>
by: Laura C. Terrón-Camero, et al.
Published: (2023-06-01)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
by: Alexandra L. Zakharenko, et al.
Published: (2023-10-01)

Short Interrupted Repeat Cassette (SIRC)—Novel Type of Repetitive DNA Element Found in <i>Arabidopsis thaliana</i>
by: Igor V. Gorbenko, et al.
Published: (2023-07-01)

Pyranodipyran Derivatives with Tyrosyl DNA Phosphodiesterase 1 Inhibitory Activities and Fluorescent Properties from <i>Aspergillus</i> sp. EGF 15-0-3
by: Xia Wei, et al.
Published: (2022-03-01)

BREVIPEDICELLUS Positively Regulates Salt-Stress Tolerance in <i>Arabidopsis thaliana</i>
by: Huixian Cai, et al.
Published: (2023-01-01)

ITPK1 Regulates Jasmonate-Controlled Root Development in <i>Arabidopsis thaliana</i>
by: Naga Jyothi Pullagurla, et al.
Published: (2023-09-01)

Immobilization of <i>Arabidopsis thaliana</i> Hydroxynitrile Lyase (<i>At</i>HNL) on EziG Opal
by: José Coloma, et al.
Published: (2020-08-01)

The Mechanisms of Molybdate Distribution and Homeostasis with Special Focus on the Model Plant <i>Arabidopsis thaliana</i>
by: Jan-Niklas Weber, et al.
Published: (2023-12-01)

Genetic Dissection of Light-Regulated Adventitious Root Induction in <i>Arabidopsis thaliana</i> Hypocotyls
by: Yinwei Zeng, et al.
Published: (2022-05-01)

Sulfur Deficiency Increases Phosphate Accumulation, Uptake, and Transport in <i>Arabidopsis thaliana</i>
by: Alaa Allahham, et al.
Published: (2020-04-01)

Transcriptomics Reveals Fast Changes in Salicylate and Jasmonate Signaling Pathways in Shoots of Carbonate-Tolerant <i>Arabidopsis thaliana</i> under Bicarbonate Exposure
by: Laura Pérez-Martín, et al.
Published: (2021-01-01)

Surveillance of Pathogenicity of <i>Rhizoctonia solani</i> Japanese Isolates with Varied Anastomosis Groups and Subgroups on <i>Arabidopsis thaliana</i>
by: Mai Mohsen Ahmed Abdelghany, et al.
Published: (2022-01-01)

Molecular Basis to Integrate Microgravity Signals into the Photoperiodic Flowering Pathway in <i>Arabidopsis thaliana</i> under Spaceflight Condition
by: Junyan Xie, et al.
Published: (2021-12-01)

The Pyla-1 Natural Accession of <i>Arabidopsis thaliana</i> Shows Little Nitrate-Induced Plasticity of Root Development
by: Silvana Porco, et al.
Published: (2022-08-01)

Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells
by: Caihong Zhou, et al.
Published: (2013-02-01)