Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Cellular senescence is identified by a living cell in irreversible and persistent cell cycle arrest in response to various cellular stresses. Senescent cells secrete senescence-associated secretory phenotype factors that can amplify cellular senescence and alter the microenvironments. Radiotherapy,...

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Bibliographic Details
Main Authors: Mengqian Li, Liting You, Jianxin Xue, You Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
cellular senescence
ionizing radiation
DNA damage
cell cycle
senolytic
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00522/full

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