Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure o...

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Bibliographic Details
Main Authors: Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:EBioMedicine
Subjects:
CBFβ
RUNX
PPI
Transcription factor inhibitor
Leukemia
Triple negative breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641630175X

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