Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization
Rapid, accurate, and quantitative characterization of immune status of patients is of utmost importance for disease diagnosis and prognosis, evaluating efficacy of immunotherapeutics and tailoring drug treatments. Immune status of patients is often dynamic and patient-specific, and such complex het...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2013-04-01
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Series: | Frontiers in Oncology |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00098/full |
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author | Weiqiang eChen Nien-Tsu eHuang Xiang eLi Zeta Tak For Yu Katsuo eKurabayashi Jianping eFu |
author_facet | Weiqiang eChen Nien-Tsu eHuang Xiang eLi Zeta Tak For Yu Katsuo eKurabayashi Jianping eFu |
author_sort | Weiqiang eChen |
collection | DOAJ |
description | Rapid, accurate, and quantitative characterization of immune status of patients is of utmost importance for disease diagnosis and prognosis, evaluating efficacy of immunotherapeutics and tailoring drug treatments. Immune status of patients is often dynamic and patient-specific, and such complex heterogeneity has made accurate, real-time measurements of patient immune status challenging in the clinical setting. Recent advances in microfluidics have demonstrated promising applications of microfluidics for immune monitoring with minimum sample requirement and rapid functional immunophenotyping capability. This review will highlight recent developments of microfluidic platforms that can perform rapid and accurate cellular functional assays on patient immune cells. We will also discuss the future potential of integrated microfluidics to perform rapid, accurate, and sensitive cellular functional assays at a single-cell resolution on different types or subpopulations of immune cells, to provide an unprecedented level of information depth on the distribution of immune cell functionalities. We envision that such microfluidic immunophenotyping tools will allow comprehensive and systems-level immunomonitoring, unlocking the potential to transform experimental clinical immunology into an information-rich science. |
first_indexed | 2024-04-13T00:34:30Z |
format | Article |
id | doaj.art-850d2de8190845a58f96cf31eca22982 |
institution | Directory Open Access Journal |
issn | 2234-943X |
language | English |
last_indexed | 2024-04-13T00:34:30Z |
publishDate | 2013-04-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Oncology |
spelling | doaj.art-850d2de8190845a58f96cf31eca229822022-12-22T03:10:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-04-01310.3389/fonc.2013.0009848692Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status CharacterizationWeiqiang eChen0Nien-Tsu eHuang1Xiang eLi2Zeta Tak For Yu3Katsuo eKurabayashi4Jianping eFu5University of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganRapid, accurate, and quantitative characterization of immune status of patients is of utmost importance for disease diagnosis and prognosis, evaluating efficacy of immunotherapeutics and tailoring drug treatments. Immune status of patients is often dynamic and patient-specific, and such complex heterogeneity has made accurate, real-time measurements of patient immune status challenging in the clinical setting. Recent advances in microfluidics have demonstrated promising applications of microfluidics for immune monitoring with minimum sample requirement and rapid functional immunophenotyping capability. This review will highlight recent developments of microfluidic platforms that can perform rapid and accurate cellular functional assays on patient immune cells. We will also discuss the future potential of integrated microfluidics to perform rapid, accurate, and sensitive cellular functional assays at a single-cell resolution on different types or subpopulations of immune cells, to provide an unprecedented level of information depth on the distribution of immune cell functionalities. We envision that such microfluidic immunophenotyping tools will allow comprehensive and systems-level immunomonitoring, unlocking the potential to transform experimental clinical immunology into an information-rich science.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00098/fullImmunophenotypingMicrofluidicsimmune cellsCellular Immune Responseimmunomonitoringfunctional immunoassays |
spellingShingle | Weiqiang eChen Nien-Tsu eHuang Xiang eLi Zeta Tak For Yu Katsuo eKurabayashi Jianping eFu Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization Frontiers in Oncology Immunophenotyping Microfluidics immune cells Cellular Immune Response immunomonitoring functional immunoassays |
title | Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization |
title_full | Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization |
title_fullStr | Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization |
title_full_unstemmed | Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization |
title_short | Emerging Microfluidic Tools for Functional Cellular Immunophenotyping: A New Potential Paradigm for Immune Status Characterization |
title_sort | emerging microfluidic tools for functional cellular immunophenotyping a new potential paradigm for immune status characterization |
topic | Immunophenotyping Microfluidics immune cells Cellular Immune Response immunomonitoring functional immunoassays |
url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00098/full |
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