Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure
Takashi Ishida, Satoshi Tanaka, Akiyuki Sakamoto, Takanobu Hirabayashi, Mikito Kawamata Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Abstract: We report a successful ultrasound-guided transversus abdominis plane (TAP) block as an ana...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-09-01
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| Series: | Local and Regional Anesthesia |
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| Online Access: | https://www.dovepress.com/plasma-ropivacaine-concentration-after-tap-block-in-a-patient-with-car-peer-reviewed-article-LRA |
| _version_ | 1818034739385204736 |
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| author | Ishida T Tanaka S Sakamoto A Hirabayashi T Kawamata M |
| author_facet | Ishida T Tanaka S Sakamoto A Hirabayashi T Kawamata M |
| author_sort | Ishida T |
| collection | DOAJ |
| description | Takashi Ishida, Satoshi Tanaka, Akiyuki Sakamoto, Takanobu Hirabayashi, Mikito Kawamata Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Abstract: We report a successful ultrasound-guided transversus abdominis plane (TAP) block as an analgesic option for minor abdominal surgery in a 66-year-old patient with cardiac, respiratory, and renal dysfunction caused by primary systemic amyloidosis. Bilateral TAP blocks with 120 mg (1.8 mg/kg) of ropivacaine provided sufficient intra- and postoperative analgesia for insertion of a continuous ambulatory peritoneal dialysis catheter. However, the plasma concentration of ropivacaine reached a maximum of 2.5 µg/mL at 15 minutes after the TAP block, a concentration that was potentially neurotoxic. Although apparent signs of local anesthetic systemic toxicity (LAST) such as convulsion or changes in an electrocardiogram were not observed, the patient became drowsy after the TAP block, which might be one of the mild symptoms of LAST. A TAP block by itself can thus be an anesthetic option for patients undergoing minor abdominal surgery. However, cardiac and renal dysfunction might influence the pharmacokinetics of a local anesthetic used, and attention should be paid to the possibility of LAST even with a low dose of a local anesthetic for patients with cardiac and renal failure. Keywords: transversus abdominis plane block, plasma concentration of ropivacaine, cardiac failure, renal dysfunction, central nervous toxicity |
| first_indexed | 2024-12-10T06:43:57Z |
| format | Article |
| id | doaj.art-850ff7c9c6ab4a7ba966c6baa0cfa716 |
| institution | Directory Open Access Journal |
| issn | 1178-7112 |
| language | English |
| last_indexed | 2024-12-10T06:43:57Z |
| publishDate | 2018-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Local and Regional Anesthesia |
| spelling | doaj.art-850ff7c9c6ab4a7ba966c6baa0cfa7162022-12-22T01:58:43ZengDove Medical PressLocal and Regional Anesthesia1178-71122018-09-01Volume 11576040791Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failureIshida TTanaka SSakamoto AHirabayashi TKawamata MTakashi Ishida, Satoshi Tanaka, Akiyuki Sakamoto, Takanobu Hirabayashi, Mikito Kawamata Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Abstract: We report a successful ultrasound-guided transversus abdominis plane (TAP) block as an analgesic option for minor abdominal surgery in a 66-year-old patient with cardiac, respiratory, and renal dysfunction caused by primary systemic amyloidosis. Bilateral TAP blocks with 120 mg (1.8 mg/kg) of ropivacaine provided sufficient intra- and postoperative analgesia for insertion of a continuous ambulatory peritoneal dialysis catheter. However, the plasma concentration of ropivacaine reached a maximum of 2.5 µg/mL at 15 minutes after the TAP block, a concentration that was potentially neurotoxic. Although apparent signs of local anesthetic systemic toxicity (LAST) such as convulsion or changes in an electrocardiogram were not observed, the patient became drowsy after the TAP block, which might be one of the mild symptoms of LAST. A TAP block by itself can thus be an anesthetic option for patients undergoing minor abdominal surgery. However, cardiac and renal dysfunction might influence the pharmacokinetics of a local anesthetic used, and attention should be paid to the possibility of LAST even with a low dose of a local anesthetic for patients with cardiac and renal failure. Keywords: transversus abdominis plane block, plasma concentration of ropivacaine, cardiac failure, renal dysfunction, central nervous toxicityhttps://www.dovepress.com/plasma-ropivacaine-concentration-after-tap-block-in-a-patient-with-car-peer-reviewed-article-LRATransversus abdominis plane blockplasma concentration of ropivacainecardiac and renal failurecentral nervous toxicity |
| spellingShingle | Ishida T Tanaka S Sakamoto A Hirabayashi T Kawamata M Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure Local and Regional Anesthesia Transversus abdominis plane block plasma concentration of ropivacaine cardiac and renal failure central nervous toxicity |
| title | Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure |
| title_full | Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure |
| title_fullStr | Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure |
| title_full_unstemmed | Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure |
| title_short | Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure |
| title_sort | plasma ropivacaine concentration after tap block in a patient with cardiac and renal failure |
| topic | Transversus abdominis plane block plasma concentration of ropivacaine cardiac and renal failure central nervous toxicity |
| url | https://www.dovepress.com/plasma-ropivacaine-concentration-after-tap-block-in-a-patient-with-car-peer-reviewed-article-LRA |
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