Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma
Background: Most existing publications on quality of life (QoL) following stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) gather information retrospectively by conducting surveys several years after treatment. The purpose of this study is therefore to provide longitudinal QoL data an...
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/6/1315 |
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| author | Paul Windisch Jörg-Christian Tonn Christoph Fürweger Felix Ehret Berndt Wowra Markus Kufeld Christian Schichor Alexander Muacevic |
| author_facet | Paul Windisch Jörg-Christian Tonn Christoph Fürweger Felix Ehret Berndt Wowra Markus Kufeld Christian Schichor Alexander Muacevic |
| author_sort | Paul Windisch |
| collection | DOAJ |
| description | Background: Most existing publications on quality of life (QoL) following stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) gather information retrospectively by conducting surveys several years after treatment. The purpose of this study is therefore to provide longitudinal QoL data and assess how changes in hearing impact QoL. Methods: Patients completed the 12-item short-form (SF-12) health survey prior to treatment and at every follow-up visit. One hundred and seventy-five patients who had complete forms prior to treatment as well as at an early and at a late follow-up were included in the analysis. For 51 of these patients, longitudinal audiometry data were available. Results: Median follow-up was 7.2 years. Patients experienced a significant reduction in the physical composite score (PCS, <i>p</i> = 0.011) compared to before treatment. The mental composite score (MCS) increased significantly (<i>p</i> = 0.032). A decrease in PCS was not significantly correlated with an increased hearing threshold on the affected but rather on the unaffected ear (r(49) = −0.32, <i>p</i> = 0.023). Conclusions: It is unclear whether the decline in the PCS is due to treatment-related toxicity or the normal decline of PCS with age. Ensuring proper hearing on the untreated ear might be crucial to ensure good QoL for patients treated with SRS for VS, though this association should be confirmed in additional studies. |
| first_indexed | 2024-03-10T13:13:36Z |
| format | Article |
| id | doaj.art-8510476106af4dcc9260fd093324db1e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:13:36Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8510476106af4dcc9260fd093324db1e2023-11-21T10:32:49ZengMDPI AGCancers2072-66942021-03-01136131510.3390/cancers13061315Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular SchwannomaPaul Windisch0Jörg-Christian Tonn1Christoph Fürweger2Felix Ehret3Berndt Wowra4Markus Kufeld5Christian Schichor6Alexander Muacevic7European Cyberknife Center, 81377 Munich, GermanyDepartment of Neurosurgery, Ludwig Maximilians University, 80331 Munich, GermanyEuropean Cyberknife Center, 81377 Munich, GermanyCharité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiation Oncology, 10178 Berlin, GermanyEuropean Cyberknife Center, 81377 Munich, GermanyEuropean Cyberknife Center, 81377 Munich, GermanyDepartment of Neurosurgery, Ludwig Maximilians University, 80331 Munich, GermanyEuropean Cyberknife Center, 81377 Munich, GermanyBackground: Most existing publications on quality of life (QoL) following stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) gather information retrospectively by conducting surveys several years after treatment. The purpose of this study is therefore to provide longitudinal QoL data and assess how changes in hearing impact QoL. Methods: Patients completed the 12-item short-form (SF-12) health survey prior to treatment and at every follow-up visit. One hundred and seventy-five patients who had complete forms prior to treatment as well as at an early and at a late follow-up were included in the analysis. For 51 of these patients, longitudinal audiometry data were available. Results: Median follow-up was 7.2 years. Patients experienced a significant reduction in the physical composite score (PCS, <i>p</i> = 0.011) compared to before treatment. The mental composite score (MCS) increased significantly (<i>p</i> = 0.032). A decrease in PCS was not significantly correlated with an increased hearing threshold on the affected but rather on the unaffected ear (r(49) = −0.32, <i>p</i> = 0.023). Conclusions: It is unclear whether the decline in the PCS is due to treatment-related toxicity or the normal decline of PCS with age. Ensuring proper hearing on the untreated ear might be crucial to ensure good QoL for patients treated with SRS for VS, though this association should be confirmed in additional studies.https://www.mdpi.com/2072-6694/13/6/1315vestibular schwannomaradiotherapyradiosurgeryquality of life |
| spellingShingle | Paul Windisch Jörg-Christian Tonn Christoph Fürweger Felix Ehret Berndt Wowra Markus Kufeld Christian Schichor Alexander Muacevic Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma Cancers vestibular schwannoma radiotherapy radiosurgery quality of life |
| title | Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma |
| title_full | Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma |
| title_fullStr | Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma |
| title_full_unstemmed | Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma |
| title_short | Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma |
| title_sort | longitudinal changes of quality of life and hearing following radiosurgery for vestibular schwannoma |
| topic | vestibular schwannoma radiotherapy radiosurgery quality of life |
| url | https://www.mdpi.com/2072-6694/13/6/1315 |
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