Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT
Background: Anal cancer (AC) is a malignancy with increasing incidence and commonly treated with radiochemotherapy. Positron-emission tomography-computed tomography (PET/CT) has been shown to improve treatment outcome in various oncological diseases, however, for AC long-term outcome data is sparse....
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Elsevier
2020-09-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630820300574 |
| _version_ | 1830131929457885184 |
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| author | L.H. Braun C.P. Reinert D. Zips K. Nikolaou C. Pfannenberg C. Gani |
| author_facet | L.H. Braun C.P. Reinert D. Zips K. Nikolaou C. Pfannenberg C. Gani |
| author_sort | L.H. Braun |
| collection | DOAJ |
| description | Background: Anal cancer (AC) is a malignancy with increasing incidence and commonly treated with radiochemotherapy. Positron-emission tomography-computed tomography (PET/CT) has been shown to improve treatment outcome in various oncological diseases, however, for AC long-term outcome data is sparse. The aim of the present study is therefore to report outcomes in our cohort of PET/CT staged AC patients treated with radiochemotherapy. Methods: Patients with AC who were treated with radiochemotherapy in curative intent were included in this retrospective study if a PET/CT scan was performed pre-therapeutically. Information from PET/CT was considered for nodal and primary target volume definition. Radiotherapy dose to the primary tumor was 50–66 Gy and concomitant chemotherapy included 5-fluorouracil and mitomycin-C. The uptake of 18F-fluorodeoxyglucose (FDG) was quantified using 50%-isocontour volumes of interests (VOIs) and measuring the standardized uptake value (SUV) and the metabolic tumor volume (MTV).18F-FDG uptake was correlated with baseline clinical parameters and long-term oncological outcome. Survival estimates were determined according to Kaplan-Meier. Results: A total of 60 patients were included in this study. Estimates for three-year overall survival (OS) and disease free survival (DFS) were 94.5% and 80%. Five patients developed local (n = 2) or locoregional and local (n = 3) failure. Baseline PET/CT related parameters correlated with primary tumor stage, nodal stage and tumor grading. DFS was independent of T-stage, N-stage and baseline 18F-FDG-uptake. Conclusion: In this cohort of PET/CT staged AC patients, excellent outcomes for DFS were seen. PET-based markers of tumor burden correlate with local stage of AC, however, are not of prognostic relevance for disease-free survival. |
| first_indexed | 2024-12-17T06:25:07Z |
| format | Article |
| id | doaj.art-851489e93793414b90e1ae8b0bd3bfde |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-12-17T06:25:07Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-851489e93793414b90e1ae8b0bd3bfde2022-12-21T22:00:18ZengElsevierClinical and Translational Radiation Oncology2405-63082020-09-01248387Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CTL.H. Braun0C.P. Reinert1D. Zips2K. Nikolaou3C. Pfannenberg4C. Gani5Department of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Germany; Klinik für Strahlentherapie und Palliativmedizin, Marienhospital Stuttgart, GermanyDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Germany; German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, GermanyDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, GermanyDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, GermanyDepartment of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Germany; German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, Germany; Corresponding author at: Department of Radiation Oncology, University Hospital and Medical Faculty Tübingen, Eberhard Karls University Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.Background: Anal cancer (AC) is a malignancy with increasing incidence and commonly treated with radiochemotherapy. Positron-emission tomography-computed tomography (PET/CT) has been shown to improve treatment outcome in various oncological diseases, however, for AC long-term outcome data is sparse. The aim of the present study is therefore to report outcomes in our cohort of PET/CT staged AC patients treated with radiochemotherapy. Methods: Patients with AC who were treated with radiochemotherapy in curative intent were included in this retrospective study if a PET/CT scan was performed pre-therapeutically. Information from PET/CT was considered for nodal and primary target volume definition. Radiotherapy dose to the primary tumor was 50–66 Gy and concomitant chemotherapy included 5-fluorouracil and mitomycin-C. The uptake of 18F-fluorodeoxyglucose (FDG) was quantified using 50%-isocontour volumes of interests (VOIs) and measuring the standardized uptake value (SUV) and the metabolic tumor volume (MTV).18F-FDG uptake was correlated with baseline clinical parameters and long-term oncological outcome. Survival estimates were determined according to Kaplan-Meier. Results: A total of 60 patients were included in this study. Estimates for three-year overall survival (OS) and disease free survival (DFS) were 94.5% and 80%. Five patients developed local (n = 2) or locoregional and local (n = 3) failure. Baseline PET/CT related parameters correlated with primary tumor stage, nodal stage and tumor grading. DFS was independent of T-stage, N-stage and baseline 18F-FDG-uptake. Conclusion: In this cohort of PET/CT staged AC patients, excellent outcomes for DFS were seen. PET-based markers of tumor burden correlate with local stage of AC, however, are not of prognostic relevance for disease-free survival.http://www.sciencedirect.com/science/article/pii/S2405630820300574Anal cancerRadiotherapyPETRadiochemotherapy |
| spellingShingle | L.H. Braun C.P. Reinert D. Zips K. Nikolaou C. Pfannenberg C. Gani Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT Clinical and Translational Radiation Oncology Anal cancer Radiotherapy PET Radiochemotherapy |
| title | Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT |
| title_full | Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT |
| title_fullStr | Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT |
| title_full_unstemmed | Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT |
| title_short | Treatment outcome after radiochemotherapy in anal cancer patients staged with 18F-FDG-PET-CT |
| title_sort | treatment outcome after radiochemotherapy in anal cancer patients staged with 18f fdg pet ct |
| topic | Anal cancer Radiotherapy PET Radiochemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630820300574 |
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