Dormancy of cutaneous melanoma
Abstract Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly reduce cancer burden, permitting dormant cancer cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-024-03278-5 |
| _version_ | 1797273175271145472 |
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| author | Kathrin Singvogel Birgit Schittek |
| author_facet | Kathrin Singvogel Birgit Schittek |
| author_sort | Kathrin Singvogel |
| collection | DOAJ |
| description | Abstract Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly reduce cancer burden, permitting dormant cancer cells to persist in niches, where they establish a cellular homeostasis with their host without causing clinical symptoms. Dormant cancers respond poorly to most drugs and therapies since they do not proliferate and hide in niches. It therefore remains a major challenge to develop novel therapies for dormant cancers. In this review we focus on the mechanisms regulating the initiation of cutaneous melanoma dormancy as well as those which are involved in reawakening of dormant cutaneous melanoma cells. In recent years the role of neutrophils and niche components in reawakening of melanoma cells came into focus and indicate possible future therapeutic applications. Sophisticated in vitro and in vivo melanoma dormancy models are needed to make progress in this field and are discussed. |
| first_indexed | 2024-03-07T14:39:49Z |
| format | Article |
| id | doaj.art-8514c7aeea1f4e29b370b60ab83e7bcd |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-07T14:39:49Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-8514c7aeea1f4e29b370b60ab83e7bcd2024-03-05T20:25:41ZengBMCCancer Cell International1475-28672024-02-0124111610.1186/s12935-024-03278-5Dormancy of cutaneous melanomaKathrin Singvogel0Birgit Schittek1Division of Dermatooncology, Department of Dermatology, University of TübingenDivision of Dermatooncology, Department of Dermatology, University of TübingenAbstract Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly reduce cancer burden, permitting dormant cancer cells to persist in niches, where they establish a cellular homeostasis with their host without causing clinical symptoms. Dormant cancers respond poorly to most drugs and therapies since they do not proliferate and hide in niches. It therefore remains a major challenge to develop novel therapies for dormant cancers. In this review we focus on the mechanisms regulating the initiation of cutaneous melanoma dormancy as well as those which are involved in reawakening of dormant cutaneous melanoma cells. In recent years the role of neutrophils and niche components in reawakening of melanoma cells came into focus and indicate possible future therapeutic applications. Sophisticated in vitro and in vivo melanoma dormancy models are needed to make progress in this field and are discussed.https://doi.org/10.1186/s12935-024-03278-5MelanomaDormant cancerNeutrophilsNETsImmunotherapy |
| spellingShingle | Kathrin Singvogel Birgit Schittek Dormancy of cutaneous melanoma Cancer Cell International Melanoma Dormant cancer Neutrophils NETs Immunotherapy |
| title | Dormancy of cutaneous melanoma |
| title_full | Dormancy of cutaneous melanoma |
| title_fullStr | Dormancy of cutaneous melanoma |
| title_full_unstemmed | Dormancy of cutaneous melanoma |
| title_short | Dormancy of cutaneous melanoma |
| title_sort | dormancy of cutaneous melanoma |
| topic | Melanoma Dormant cancer Neutrophils NETs Immunotherapy |
| url | https://doi.org/10.1186/s12935-024-03278-5 |
| work_keys_str_mv | AT kathrinsingvogel dormancyofcutaneousmelanoma AT birgitschittek dormancyofcutaneousmelanoma |