Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells

Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells

Abstract Background Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal and multipotent properties, which depend on their ability to maintain qui...

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Bibliographic Details
Main Authors: Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles, Gregory David
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Epigenetics & Chromatin
Subjects:
Hematopoiesis
Cell cycle
Differentiation
Stem cells
Chromatin
Online Access:https://doi.org/10.1186/s13072-024-00526-w

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