IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels
We and others have shown that regulatory T cells (Treg) accumulate dramatically with age in both humans and mice. Such Treg accrual contributes to age-related immunosenescence as they reduce the response to tumors and parasite infection. While we reported earlier that aged Treg have decreased expr...
Main Authors: | Jana eRaynor, Allyson eSholl, David R. Plas, Philippe eBouillet, Claire A Chougnet, David A Hildeman |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00161/full |
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