Drug Stability Analysis by Raman Spectroscopy
Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space, losing their potency before their expiration date...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-12-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/6/4/651 |
| _version_ | 1798043561680175104 |
|---|---|
| author | Chetan Shende Wayne Smith Carl Brouillette Stuart Farquharson |
| author_facet | Chetan Shende Wayne Smith Carl Brouillette Stuart Farquharson |
| author_sort | Chetan Shende |
| collection | DOAJ |
| description | Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space, losing their potency before their expiration dates. To complicate matters, the degradation products of some drugs can be toxic. Here, we present a preliminary investigation of the ability of Raman spectroscopy to quantify mixtures of four drugs; acetaminophen, azithromycin, epinephrine, and lidocaine, with their primary degradation products. The Raman spectra for the mixtures were replicated by adding the pure spectra of the drug and its degradant to determine the relative percent contributions using classical least squares. This multivariate approach allowed determining concentrations in ~10 min with a limit of detection of ~4% of the degradant. These results suggest that a Raman analyzer could be used to assess drug potency, nondestructively, at the time of use to ensure crewmember safety. |
| first_indexed | 2024-04-11T22:50:50Z |
| format | Article |
| id | doaj.art-8516360ca750471c94a09bbe3ab48978 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:50:50Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8516360ca750471c94a09bbe3ab489782022-12-22T03:58:35ZengMDPI AGPharmaceutics1999-49232014-12-016465166210.3390/pharmaceutics6040651pharmaceutics6040651Drug Stability Analysis by Raman SpectroscopyChetan Shende0Wayne Smith1Carl Brouillette2Stuart Farquharson3Real-Time Analyzers, Inc., Middletown, CT 06457, USAReal-Time Analyzers, Inc., Middletown, CT 06457, USAReal-Time Analyzers, Inc., Middletown, CT 06457, USAReal-Time Analyzers, Inc., Middletown, CT 06457, USAPharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space, losing their potency before their expiration dates. To complicate matters, the degradation products of some drugs can be toxic. Here, we present a preliminary investigation of the ability of Raman spectroscopy to quantify mixtures of four drugs; acetaminophen, azithromycin, epinephrine, and lidocaine, with their primary degradation products. The Raman spectra for the mixtures were replicated by adding the pure spectra of the drug and its degradant to determine the relative percent contributions using classical least squares. This multivariate approach allowed determining concentrations in ~10 min with a limit of detection of ~4% of the degradant. These results suggest that a Raman analyzer could be used to assess drug potency, nondestructively, at the time of use to ensure crewmember safety.http://www.mdpi.com/1999-4923/6/4/651drug stability analysisdrug degradationRaman spectroscopymultivariate analysisastronaut health |
| spellingShingle | Chetan Shende Wayne Smith Carl Brouillette Stuart Farquharson Drug Stability Analysis by Raman Spectroscopy Pharmaceutics drug stability analysis drug degradation Raman spectroscopy multivariate analysis astronaut health |
| title | Drug Stability Analysis by Raman Spectroscopy |
| title_full | Drug Stability Analysis by Raman Spectroscopy |
| title_fullStr | Drug Stability Analysis by Raman Spectroscopy |
| title_full_unstemmed | Drug Stability Analysis by Raman Spectroscopy |
| title_short | Drug Stability Analysis by Raman Spectroscopy |
| title_sort | drug stability analysis by raman spectroscopy |
| topic | drug stability analysis drug degradation Raman spectroscopy multivariate analysis astronaut health |
| url | http://www.mdpi.com/1999-4923/6/4/651 |
| work_keys_str_mv | AT chetanshende drugstabilityanalysisbyramanspectroscopy AT waynesmith drugstabilityanalysisbyramanspectroscopy AT carlbrouillette drugstabilityanalysisbyramanspectroscopy AT stuartfarquharson drugstabilityanalysisbyramanspectroscopy |