HLA-G and Recurrent Pregnancy Loss
Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2557 |
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| author | Greta Barbaro Annalisa Inversetti Martina Cristodoro Carlo Ticconi Giovanni Scambia Nicoletta Di Simone |
| author_facet | Greta Barbaro Annalisa Inversetti Martina Cristodoro Carlo Ticconi Giovanni Scambia Nicoletta Di Simone |
| author_sort | Greta Barbaro |
| collection | DOAJ |
| description | Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune response. The prevalence of recurrent pregnancy loss (RPL), probably underestimated, is 5% of all women who achieve pregnancy, and about 40–60% percent of RPL cases are unexplained. There is an immunological analogy between allograft rejection and miscarriage, and the purpose of this review is to describe how the HLA-G pathway alterations are involved in disrupting the immunologic balance and in increasing the risk of recurrent pregnancy loss. |
| first_indexed | 2024-03-11T09:40:58Z |
| format | Article |
| id | doaj.art-851694f71c044938804c5cfc45af75af |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:40:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-851694f71c044938804c5cfc45af75af2023-11-16T16:59:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243255710.3390/ijms24032557HLA-G and Recurrent Pregnancy LossGreta Barbaro0Annalisa Inversetti1Martina Cristodoro2Carlo Ticconi3Giovanni Scambia4Nicoletta Di Simone5Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.), L. go A. Gemelli 8, 00168 Roma, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milano, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milano, ItalyDipartimento di Scienze Chirurgiche, Ginecologia e Ostetricia, Università di Torvergata, 00168 Roma, ItalyDipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.), L. go A. Gemelli 8, 00168 Roma, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milano, ItalyPlacentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune response. The prevalence of recurrent pregnancy loss (RPL), probably underestimated, is 5% of all women who achieve pregnancy, and about 40–60% percent of RPL cases are unexplained. There is an immunological analogy between allograft rejection and miscarriage, and the purpose of this review is to describe how the HLA-G pathway alterations are involved in disrupting the immunologic balance and in increasing the risk of recurrent pregnancy loss.https://www.mdpi.com/1422-0067/24/3/2557HLA-Grecurrent pregnancy losstrophoblastplacentation |
| spellingShingle | Greta Barbaro Annalisa Inversetti Martina Cristodoro Carlo Ticconi Giovanni Scambia Nicoletta Di Simone HLA-G and Recurrent Pregnancy Loss International Journal of Molecular Sciences HLA-G recurrent pregnancy loss trophoblast placentation |
| title | HLA-G and Recurrent Pregnancy Loss |
| title_full | HLA-G and Recurrent Pregnancy Loss |
| title_fullStr | HLA-G and Recurrent Pregnancy Loss |
| title_full_unstemmed | HLA-G and Recurrent Pregnancy Loss |
| title_short | HLA-G and Recurrent Pregnancy Loss |
| title_sort | hla g and recurrent pregnancy loss |
| topic | HLA-G recurrent pregnancy loss trophoblast placentation |
| url | https://www.mdpi.com/1422-0067/24/3/2557 |
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