Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior
Abstract The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significant role in many processes, mice deficient in HCAR1 exhibit no visible phenotype and are healthy and fertile. We performed transcriptomic analysis on HCAR1 deficient cells...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01188-z |
| _version_ | 1827709323075125248 |
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| author | Mohammad Ali Mohammad Nezhady Gael Cagnone Jean-Sébastien Joyal Sylvain Chemtob |
| author_facet | Mohammad Ali Mohammad Nezhady Gael Cagnone Jean-Sébastien Joyal Sylvain Chemtob |
| author_sort | Mohammad Ali Mohammad Nezhady |
| collection | DOAJ |
| description | Abstract The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significant role in many processes, mice deficient in HCAR1 exhibit no visible phenotype and are healthy and fertile. We performed transcriptomic analysis on HCAR1 deficient cells, in combination with lactate, to explore pathophysiologically altered processes. Processes such as immune regulation, various cancers, and neurodegenerative diseases were significantly enriched for HCAR1 transcriptomic signature. However, the most affected process of all was autism spectrum disorder. We performed behavioral tests on HCAR1 KO mice and observed that these mice manifest autistic-like behavior. Our data opens new avenues for research on HCAR1 and lactate effect at a pathological level. Video Abstract |
| first_indexed | 2024-03-10T17:20:31Z |
| format | Article |
| id | doaj.art-851871c6b90e45f5bef76bcec45d9e36 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-10T17:20:31Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-851871c6b90e45f5bef76bcec45d9e362023-11-20T10:21:50ZengBMCCell Communication and Signaling1478-811X2023-11-012111710.1186/s12964-023-01188-zLack of HCAR1, the lactate GPCR, signaling promotes autistic-like behaviorMohammad Ali Mohammad Nezhady0Gael Cagnone1Jean-Sébastien Joyal2Sylvain Chemtob3Program in Molecular Biology, Faculty of Medicine, University of MontrealDepartment of Pediatrics, Sainte-Justine University Hospital Research Center, University of MontrealDepartment of Pediatrics, Sainte-Justine University Hospital Research Center, University of MontrealProgram in Molecular Biology, Faculty of Medicine, University of MontrealAbstract The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significant role in many processes, mice deficient in HCAR1 exhibit no visible phenotype and are healthy and fertile. We performed transcriptomic analysis on HCAR1 deficient cells, in combination with lactate, to explore pathophysiologically altered processes. Processes such as immune regulation, various cancers, and neurodegenerative diseases were significantly enriched for HCAR1 transcriptomic signature. However, the most affected process of all was autism spectrum disorder. We performed behavioral tests on HCAR1 KO mice and observed that these mice manifest autistic-like behavior. Our data opens new avenues for research on HCAR1 and lactate effect at a pathological level. Video Abstracthttps://doi.org/10.1186/s12964-023-01188-zLactateHCAR1GPCRSignalingAutism spectrum disorderAutistic-like behavior |
| spellingShingle | Mohammad Ali Mohammad Nezhady Gael Cagnone Jean-Sébastien Joyal Sylvain Chemtob Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior Cell Communication and Signaling Lactate HCAR1 GPCR Signaling Autism spectrum disorder Autistic-like behavior |
| title | Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior |
| title_full | Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior |
| title_fullStr | Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior |
| title_full_unstemmed | Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior |
| title_short | Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior |
| title_sort | lack of hcar1 the lactate gpcr signaling promotes autistic like behavior |
| topic | Lactate HCAR1 GPCR Signaling Autism spectrum disorder Autistic-like behavior |
| url | https://doi.org/10.1186/s12964-023-01188-z |
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