The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis

The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investi...

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Bibliographic Details
Main Authors: Akbulut Ekrem, Yolbas Servet, Ozgen Metin
Format: Article
Language:English
Published: De Gruyter 2021-07-01
Series:Türk Biyokimya Dergisi
Subjects:
axial spondyloarthritis
disease risk
inflammation
peroxisome proliferator activated receptor alpha
polymorphism
aksiyal spondiloartrit
hastalık riski
enflamasyon
peroksizom çoğaltıcılar tarafından aktive edilen reseptör alfa
polimorfizm
Online Access:https://doi.org/10.1515/tjb-2021-0086
Description
Summary:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.Ala268Val polymorphism of PPARA with axSpA risk and its role in disease development.
ISSN:1303-829X

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