The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-07-01
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| Series: | Türk Biyokimya Dergisi |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tjb-2021-0086 |
| _version_ | 1818744632252563456 |
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| author | Akbulut Ekrem Yolbas Servet Ozgen Metin |
| author_facet | Akbulut Ekrem Yolbas Servet Ozgen Metin |
| author_sort | Akbulut Ekrem |
| collection | DOAJ |
| description | Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.Ala268Val polymorphism of PPARA with axSpA risk and its role in disease development. |
| first_indexed | 2024-12-18T02:47:23Z |
| format | Article |
| id | doaj.art-851a493247824ea180657996e5b3699e |
| institution | Directory Open Access Journal |
| issn | 1303-829X |
| language | English |
| last_indexed | 2024-12-18T02:47:23Z |
| publishDate | 2021-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj.art-851a493247824ea180657996e5b3699e2022-12-21T21:23:32ZengDe GruyterTürk Biyokimya Dergisi1303-829X2021-07-0147110311110.1515/tjb-2021-0086The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritisAkbulut Ekrem0Yolbas Servet1Ozgen Metin2Department of Bioengineering, Faculty of Engineering and Natural Sciences, Malatya Turgut Özal University, Malatya, TurkeyDepartment of Rheumatology, Faculty of Medicine, İnonu University, Malatya, TurkeyDepartment of Rheumatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, TurkeyAxial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.Ala268Val polymorphism of PPARA with axSpA risk and its role in disease development.https://doi.org/10.1515/tjb-2021-0086axial spondyloarthritisdisease riskinflammationperoxisome proliferator activated receptor alphapolymorphismaksiyal spondiloartrithastalık riskienflamasyonperoksizom çoğaltıcılar tarafından aktive edilen reseptör alfapolimorfizm |
| spellingShingle | Akbulut Ekrem Yolbas Servet Ozgen Metin The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis Türk Biyokimya Dergisi axial spondyloarthritis disease risk inflammation peroxisome proliferator activated receptor alpha polymorphism aksiyal spondiloartrit hastalık riski enflamasyon peroksizom çoğaltıcılar tarafından aktive edilen reseptör alfa polimorfizm |
| title | The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis |
| title_full | The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis |
| title_fullStr | The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis |
| title_full_unstemmed | The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis |
| title_short | The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis |
| title_sort | role of a268v exon 7 polymorphism of ppara in development of axial spondyloarthritis |
| topic | axial spondyloarthritis disease risk inflammation peroxisome proliferator activated receptor alpha polymorphism aksiyal spondiloartrit hastalık riski enflamasyon peroksizom çoğaltıcılar tarafından aktive edilen reseptör alfa polimorfizm |
| url | https://doi.org/10.1515/tjb-2021-0086 |
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