Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or via Downstream Effectors to Modulate Igf3 Effects on Zebrafish Spermatogenesis

Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or via Downstream Effectors to Modulate Igf3 Effects on Zebrafish Spermatogenesis

Previous work showed that pharmacological inactivation of Igf-binding proteins (Igfbps), modulators of Igf activity, resulted in an excessive differentiation of type A undifferentiated (Aund) spermatogonia in zebrafish testis in tissue culture when Fsh was present in the incubation medium. Using thi...

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Bibliographic Details
Main Authors: Diego Safian, Henk J. G. van der Kant, Diego Crespo, Jan Bogerd, Rüdiger W. Schulz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Endocrinology
Subjects:
follicle-stimulating hormone
Igf3
Igf-binding proteins
spermatogonia
differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00328/full

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