Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report
We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1026434/full |
| _version_ | 1811170758014009344 |
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| author | François Poumeaud Anna Fontanier Jérémie Dion Quentin Mathevet Olivier Cointault Emmanuelle Uro-Coste Céline Marty Florence Dalenc Pierre Girardie Anaïs Rataboul |
| author_facet | François Poumeaud Anna Fontanier Jérémie Dion Quentin Mathevet Olivier Cointault Emmanuelle Uro-Coste Céline Marty Florence Dalenc Pierre Girardie Anaïs Rataboul |
| author_sort | François Poumeaud |
| collection | DOAJ |
| description | We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event. |
| first_indexed | 2024-04-10T17:01:55Z |
| format | Article |
| id | doaj.art-851e524cbd1f4b2685d5a5f1fcd51854 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T17:01:55Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-851e524cbd1f4b2685d5a5f1fcd518542023-02-06T09:18:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10264341026434Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case reportFrançois Poumeaud0Anna Fontanier1Jérémie Dion2Quentin Mathevet3Olivier Cointault4Emmanuelle Uro-Coste5Céline Marty6Florence Dalenc7Pierre Girardie8Anaïs Rataboul9Department of Medical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceDepartment of Clinical Pharmacy, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceDepartment of Internal Medicine and Clinical Immunology, Centre Hospitalier Universitaire Toulouse, Toulouse, FranceDepartment of Clinical Pharmacy, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceDepartment of Nephrology, Centre Hospitalier Universitaire Toulouse, Toulouse, FranceDepartment of Anatomo-pathology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, FranceDepartment of Clinical Pharmacy, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceDepartment of Medical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceDepartment of Neurology, Centre Hospitalier Universitai Toulouse – Purpan, Toulouse, FranceDepartment of Medical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, FranceWe report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.https://www.frontiersin.org/articles/10.3389/fonc.2022.1026434/fullrhabdomyolysispalbociclibsimvastatininteractionmyositisplasmatic exchange |
| spellingShingle | François Poumeaud Anna Fontanier Jérémie Dion Quentin Mathevet Olivier Cointault Emmanuelle Uro-Coste Céline Marty Florence Dalenc Pierre Girardie Anaïs Rataboul Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report Frontiers in Oncology rhabdomyolysis palbociclib simvastatin interaction myositis plasmatic exchange |
| title | Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report |
| title_full | Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report |
| title_fullStr | Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report |
| title_full_unstemmed | Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report |
| title_short | Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report |
| title_sort | severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment a case report |
| topic | rhabdomyolysis palbociclib simvastatin interaction myositis plasmatic exchange |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1026434/full |
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