NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Abstract Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6J mice were intraperitoneally injected with 20 mg/Kg DOX to induce heart injury. A...

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Bibliographic Details
Main Authors: Yi Wang, Yuxin Zan, Yingying Huang, Xiaoyun Peng, Shinan Ma, Ji Ren, Xiao Li, Lin Wei, Xiaoli Wang, Yahong Yuan, Junming Tang, Zhongqun Zhan, Zhixiao Wang, Yan Ding
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01294-w

Internet

https://doi.org/10.1038/s41420-022-01294-w

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