Conditioned Medium from Mesenchymal Stem Cells Alleviates Endothelial Dysfunction of Vascular Grafts Submitted to Ischemia/Reperfusion Injury in 15-Month-Old Rats

Conditioned Medium from Mesenchymal Stem Cells Alleviates Endothelial Dysfunction of Vascular Grafts Submitted to Ischemia/Reperfusion Injury in 15-Month-Old Rats

In patients undergoing coronary artery bypass grafting (CABG), ischemia/reperfusion injury (IRI) is the main contributor to organ dysfunction. Aging-induced vascular damage may be further aggravated during CABG. Favorable effects of conditioned medium (CM) from mesenchymal stem cells (MSCs) have bee...

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Bibliographic Details
Main Authors: Sevil Korkmaz-Icöz, Xiaoxin Sun, Shiliang Li, Paige Brlecic, Sivakkanan Loganathan, Mihály Ruppert, Alex Ali Sayour, Tamás Radovits, Matthias Karck, Gábor Szabó
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
ischemia/reperfusion
endothelial function
mesenchymal stem cells
conditioned medium
caspase-12
Online Access:https://www.mdpi.com/2073-4409/10/5/1231

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