Content/Potency Assessment of Botulinum Neurotoxin Type-A by Validated Liquid Chromatography Methods and Bioassays
Botulinum neurotoxin type-A (BoNTA) is one of the seven different serotypes (A to G) produced by Clostridium botulinum. A stability-indicating size-exclusion chromatography (SEC) method was developed and validated, and the specificity was confirmed by forced degradation study, interference of the ex...
Main Authors: | Bruna Xavier, Rafaela Ferreira Perobelli, Maurício Elesbão Walter, Francielle Santos da Silva, Sérgio Luiz Dalmora |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-01-01
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Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/11/1/35 |
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