A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome
Understanding hierarchy and modularity in natural as well as technological networks is of utmost importance. A major aspect of such analysis involves identifying the nodes that are crucial to the overall processing structure of the network. More recently, the approach of hourglass analysis has been...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550382/?tool=EBI |
| _version_ | 1819025324126502912 |
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| author | Ishaan Batta Qihang Yao Kaeser M. Sabrin Constantine Dovrolis |
| author_facet | Ishaan Batta Qihang Yao Kaeser M. Sabrin Constantine Dovrolis |
| author_sort | Ishaan Batta |
| collection | DOAJ |
| description | Understanding hierarchy and modularity in natural as well as technological networks is of utmost importance. A major aspect of such analysis involves identifying the nodes that are crucial to the overall processing structure of the network. More recently, the approach of hourglass analysis has been developed for the purpose of quantitatively analyzing whether only a few intermediate nodes mediate the information processing between a large number of inputs and outputs of a network. We develop a new framework for hourglass analysis that takes network weights into account while identifying the core nodes and the extent of hourglass effect in a given weighted network. We use this framework to study the structural connectome of the C. elegans and identify intermediate neurons that form the core of sensori-motor pathways in the organism. Our results show that the neurons forming the core of the connectome show significant differences across the male and hermaphrodite sexes, with most core nodes in the male concentrated in sex-organs while they are located in the head for the hermaphrodite. Our work demonstrates that taking weights into account for network analysis framework leads to emergence of different network patterns in terms of identification of core nodes and hourglass structure in the network, which otherwise would be missed by unweighted approaches. |
| first_indexed | 2024-12-21T05:08:52Z |
| format | Article |
| id | doaj.art-85217693147f4947acd74f44665d1980 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T05:08:52Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-85217693147f4947acd74f44665d19802022-12-21T19:15:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectomeIshaan BattaQihang YaoKaeser M. SabrinConstantine DovrolisUnderstanding hierarchy and modularity in natural as well as technological networks is of utmost importance. A major aspect of such analysis involves identifying the nodes that are crucial to the overall processing structure of the network. More recently, the approach of hourglass analysis has been developed for the purpose of quantitatively analyzing whether only a few intermediate nodes mediate the information processing between a large number of inputs and outputs of a network. We develop a new framework for hourglass analysis that takes network weights into account while identifying the core nodes and the extent of hourglass effect in a given weighted network. We use this framework to study the structural connectome of the C. elegans and identify intermediate neurons that form the core of sensori-motor pathways in the organism. Our results show that the neurons forming the core of the connectome show significant differences across the male and hermaphrodite sexes, with most core nodes in the male concentrated in sex-organs while they are located in the head for the hermaphrodite. Our work demonstrates that taking weights into account for network analysis framework leads to emergence of different network patterns in terms of identification of core nodes and hourglass structure in the network, which otherwise would be missed by unweighted approaches.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550382/?tool=EBI |
| spellingShingle | Ishaan Batta Qihang Yao Kaeser M. Sabrin Constantine Dovrolis A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome PLoS ONE |
| title | A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome |
| title_full | A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome |
| title_fullStr | A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome |
| title_full_unstemmed | A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome |
| title_short | A weighted network analysis framework for the hourglass effect—And its application in the C. elegans connectome |
| title_sort | weighted network analysis framework for the hourglass effect and its application in the c elegans connectome |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550382/?tool=EBI |
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