Retinal oxygen metabolism in patients with mild cognitive impairment
Abstract Introduction We have previously reported that retinal vessel oxygen saturation is increased in mild‐to‐moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. The main purpose was to investig...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2018.03.002 |
| _version_ | 1818912193255571456 |
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| author | Olof Birna Olafsdottir Hrafnhildur Sif Saevarsdottir Sveinn Hakon Hardarson Kristin Hanna Hannesdottir Valgerdur Dora Traustadottir Robert Arnar Karlsson Anna Bryndis Einarsdottir Katrin Dilja Jonsdottir Einar Stefansson Jon Snaedal |
| author_facet | Olof Birna Olafsdottir Hrafnhildur Sif Saevarsdottir Sveinn Hakon Hardarson Kristin Hanna Hannesdottir Valgerdur Dora Traustadottir Robert Arnar Karlsson Anna Bryndis Einarsdottir Katrin Dilja Jonsdottir Einar Stefansson Jon Snaedal |
| author_sort | Olof Birna Olafsdottir |
| collection | DOAJ |
| description | Abstract Introduction We have previously reported that retinal vessel oxygen saturation is increased in mild‐to‐moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. The main purpose was to investigate if these changes are seen in MCI. Methods Retinal vessel oxygen saturation was measured in 42 patients with MCI and 42 healthy individuals with a noninvasive retinal oximeter, Oxymap T1. The groups were paired according to age. Results Arteriolar and venular oxygen saturation was increased in MCI patients compared to healthy individuals (arterioles: 93.1 ± 3.7% vs. 91.1 ± 3.4%, P = .01; venules: 59.6 ± 6.1% vs. 54.9 ± 6.4%, P = .001). Arteriovenous difference was decreased in MCI compared to healthy individuals (33.5 ± 4.5% vs. 36.2 ± 5.2%, P = .01). Discussion Increased retinal vessel oxygen saturation and decreased arteriovenous difference in MCI could reflect less oxygen extraction by retinal tissue. This indicates that retinal oxygen metabolism may be affected in patients with MCI. |
| first_indexed | 2024-12-19T23:10:42Z |
| format | Article |
| id | doaj.art-8521e69328c54203b928725f4a422afc |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-19T23:10:42Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-8521e69328c54203b928725f4a422afc2022-12-21T20:02:14ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110134034510.1016/j.dadm.2018.03.002Retinal oxygen metabolism in patients with mild cognitive impairmentOlof Birna Olafsdottir0Hrafnhildur Sif Saevarsdottir1Sveinn Hakon Hardarson2Kristin Hanna Hannesdottir3Valgerdur Dora Traustadottir4Robert Arnar Karlsson5Anna Bryndis Einarsdottir6Katrin Dilja Jonsdottir7Einar Stefansson8Jon Snaedal9Department of OphthalmologyLandspitali ‐ National University HospitalReykjavikIcelandUniversity of IcelandReykjavikIcelandUniversity of IcelandReykjavikIcelandDepartment of GeriatricsLandspitali ‐ National University HospitalReykjavikIcelandDepartment of OphthalmologyLandspitali ‐ National University HospitalReykjavikIcelandDepartment of OphthalmologyLandspitali ‐ National University HospitalReykjavikIcelandOdense University HospitalOdenseDenmarkDepartment of OphthalmologyLandspitali ‐ National University HospitalReykjavikIcelandDepartment of OphthalmologyLandspitali ‐ National University HospitalReykjavikIcelandDepartment of GeriatricsLandspitali ‐ National University HospitalReykjavikIcelandAbstract Introduction We have previously reported that retinal vessel oxygen saturation is increased in mild‐to‐moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. The main purpose was to investigate if these changes are seen in MCI. Methods Retinal vessel oxygen saturation was measured in 42 patients with MCI and 42 healthy individuals with a noninvasive retinal oximeter, Oxymap T1. The groups were paired according to age. Results Arteriolar and venular oxygen saturation was increased in MCI patients compared to healthy individuals (arterioles: 93.1 ± 3.7% vs. 91.1 ± 3.4%, P = .01; venules: 59.6 ± 6.1% vs. 54.9 ± 6.4%, P = .001). Arteriovenous difference was decreased in MCI compared to healthy individuals (33.5 ± 4.5% vs. 36.2 ± 5.2%, P = .01). Discussion Increased retinal vessel oxygen saturation and decreased arteriovenous difference in MCI could reflect less oxygen extraction by retinal tissue. This indicates that retinal oxygen metabolism may be affected in patients with MCI.https://doi.org/10.1016/j.dadm.2018.03.002Mild cognitive impairmentAlzheimer's diseaseOximetryRetinaRetinal vesselsOxygen saturation |
| spellingShingle | Olof Birna Olafsdottir Hrafnhildur Sif Saevarsdottir Sveinn Hakon Hardarson Kristin Hanna Hannesdottir Valgerdur Dora Traustadottir Robert Arnar Karlsson Anna Bryndis Einarsdottir Katrin Dilja Jonsdottir Einar Stefansson Jon Snaedal Retinal oxygen metabolism in patients with mild cognitive impairment Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Mild cognitive impairment Alzheimer's disease Oximetry Retina Retinal vessels Oxygen saturation |
| title | Retinal oxygen metabolism in patients with mild cognitive impairment |
| title_full | Retinal oxygen metabolism in patients with mild cognitive impairment |
| title_fullStr | Retinal oxygen metabolism in patients with mild cognitive impairment |
| title_full_unstemmed | Retinal oxygen metabolism in patients with mild cognitive impairment |
| title_short | Retinal oxygen metabolism in patients with mild cognitive impairment |
| title_sort | retinal oxygen metabolism in patients with mild cognitive impairment |
| topic | Mild cognitive impairment Alzheimer's disease Oximetry Retina Retinal vessels Oxygen saturation |
| url | https://doi.org/10.1016/j.dadm.2018.03.002 |
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