Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease
Abstract Background Remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) ratio has been shown to be a good predictor of metabolic disease risk, but no studies have further investigated the role of RC/HDL-C ratio in non-alcoholic fatty liver disease (NAFLD) patients. Methods The partic...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02216-x |
| _version_ | 1818358501305483264 |
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| author | Yang Zou Chong Hu Maobin Kuang Yuliang Chai |
| author_facet | Yang Zou Chong Hu Maobin Kuang Yuliang Chai |
| author_sort | Yang Zou |
| collection | DOAJ |
| description | Abstract Background Remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) ratio has been shown to be a good predictor of metabolic disease risk, but no studies have further investigated the role of RC/HDL-C ratio in non-alcoholic fatty liver disease (NAFLD) patients. Methods The participants were 14,251 adults who underwent a physical examination, all of whom underwent abdominal ultrasonography to determine whether they had NAFLD. Receiver operating characteristic curve analysis and multivariate logistic regression models were used to assess the association between the RC/HDL-C ratio and the risk of NAFLD. Results Multivariate logistic regression analysis showed that after fully adjusting the confounding factors, the higher RC/HDL-C ratio was independently positively correlated with the risk of NAFLD. Interaction tests suggested that the effect of RC/HDL-C ratio on NAFLD was significantly affected by sex. Additionally, receiver operating characteristic curve analysis showed that the area under the curve of RC/HDL-C ratio for identifying NAFLD was 0.82, which was significantly higher than that of other conventional lipid parameters. Conclusions This study indicates for the first time that the higher RC/HDL-C ratio in the general population may be closely related to the increased risk of NAFLD. |
| first_indexed | 2024-12-13T20:30:00Z |
| format | Article |
| id | doaj.art-852349f44e444539b0e3b2f00332d99e |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T20:30:00Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-852349f44e444539b0e3b2f00332d99e2022-12-21T23:32:28ZengBMCBMC Gastroenterology1471-230X2022-03-012211910.1186/s12876-022-02216-xRemnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver diseaseYang Zou0Chong Hu1Maobin Kuang2Yuliang Chai3Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeGastroenterology Department, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeCardiology Department, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeAbstract Background Remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) ratio has been shown to be a good predictor of metabolic disease risk, but no studies have further investigated the role of RC/HDL-C ratio in non-alcoholic fatty liver disease (NAFLD) patients. Methods The participants were 14,251 adults who underwent a physical examination, all of whom underwent abdominal ultrasonography to determine whether they had NAFLD. Receiver operating characteristic curve analysis and multivariate logistic regression models were used to assess the association between the RC/HDL-C ratio and the risk of NAFLD. Results Multivariate logistic regression analysis showed that after fully adjusting the confounding factors, the higher RC/HDL-C ratio was independently positively correlated with the risk of NAFLD. Interaction tests suggested that the effect of RC/HDL-C ratio on NAFLD was significantly affected by sex. Additionally, receiver operating characteristic curve analysis showed that the area under the curve of RC/HDL-C ratio for identifying NAFLD was 0.82, which was significantly higher than that of other conventional lipid parameters. Conclusions This study indicates for the first time that the higher RC/HDL-C ratio in the general population may be closely related to the increased risk of NAFLD.https://doi.org/10.1186/s12876-022-02216-xRemnant cholesterol/high-density lipoprotein cholesterol ratioRemnant cholesterolHigh-density lipoprotein cholesterolNon-alcoholic fatty liver diseaseRC/HDL-C ratio |
| spellingShingle | Yang Zou Chong Hu Maobin Kuang Yuliang Chai Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease BMC Gastroenterology Remnant cholesterol/high-density lipoprotein cholesterol ratio Remnant cholesterol High-density lipoprotein cholesterol Non-alcoholic fatty liver disease RC/HDL-C ratio |
| title | Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease |
| title_full | Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease |
| title_fullStr | Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease |
| title_full_unstemmed | Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease |
| title_short | Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease |
| title_sort | remnant cholesterol high density lipoprotein cholesterol ratio is a new powerful tool for identifying non alcoholic fatty liver disease |
| topic | Remnant cholesterol/high-density lipoprotein cholesterol ratio Remnant cholesterol High-density lipoprotein cholesterol Non-alcoholic fatty liver disease RC/HDL-C ratio |
| url | https://doi.org/10.1186/s12876-022-02216-x |
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