Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypothes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7017 |
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| author | Daniel Dumitru Banciu Dragoș Crețoiu Sanda Maria Crețoiu Adela Banciu Daniel Popa Rodica David Cristian Stefan Berghea-Neamtu Calin Remus Cipaian Mihai Octavian Negrea Mihaela Gheonea Bogdan Neamtu |
| author_facet | Daniel Dumitru Banciu Dragoș Crețoiu Sanda Maria Crețoiu Adela Banciu Daniel Popa Rodica David Cristian Stefan Berghea-Neamtu Calin Remus Cipaian Mihai Octavian Negrea Mihaela Gheonea Bogdan Neamtu |
| author_sort | Daniel Dumitru Banciu |
| collection | DOAJ |
| description | This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illustrate TCs’ possible roles in the normal and pathological functioning of the digestive tract. TCs are influenced by the compression of nearby blood vessels and the degree of fibrosis of the surrounding tissues and mediate these processes in response. The changes in intestinal tube vascularization induced by the movement of the food bowl, and the consequent pH changes that show an anisotropy in the thickness of the intestinal tube wall, have led to the identification of a pattern of intestinal tube development based on telocytes’ ability to communicate and modulate surrounding cell functions. In the construction of the theoretical model, given the predictable occurrence of colic in the infant, the two-layer arrangement of the nerve plexuses associated with the intestinal tube was considered to be incompletely adapted to the motility required with a diversified diet. There is resulting evidence of possible therapeutic targets for diseases associated with changes in local nerve tissue development. |
| first_indexed | 2024-03-09T21:51:00Z |
| format | Article |
| id | doaj.art-85241659bc2141dca4178f290869f8b4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:51:00Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-85241659bc2141dca4178f290869f8b42023-11-23T20:06:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313701710.3390/ijms23137017Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature ReviewDaniel Dumitru Banciu0Dragoș Crețoiu1Sanda Maria Crețoiu2Adela Banciu3Daniel Popa4Rodica David5Cristian Stefan Berghea-Neamtu6Calin Remus Cipaian7Mihai Octavian Negrea8Mihaela Gheonea9Bogdan Neamtu10Department of Bioengineering and Biotechnology, Faculty of Medical Engineering, Polytechnic University of Bucharest, 011061 Bucharest, RomaniaDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Bioengineering and Biotechnology, Faculty of Medical Engineering, Polytechnic University of Bucharest, 011061 Bucharest, RomaniaFaculty of Medicine, “Lucian Blaga” University, 550024 Sibiu, RomaniaInstitute for Research on the Quality of Society and the Sciences of Education, University Constantin Brancusi of Targu Jiu, Republicii 1, 210185 Targu Jiu, RomaniaFaculty of Medicine, “Lucian Blaga” University, 550024 Sibiu, RomaniaFaculty of Medicine, “Lucian Blaga” University, 550024 Sibiu, RomaniaFaculty of Medicine, “Lucian Blaga” University, 550024 Sibiu, RomaniaDepartment of Neonatology, University Emergency County Hospital, 200642 Craiova, RomaniaFaculty of Medicine, “Lucian Blaga” University, 550024 Sibiu, RomaniaThis review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illustrate TCs’ possible roles in the normal and pathological functioning of the digestive tract. TCs are influenced by the compression of nearby blood vessels and the degree of fibrosis of the surrounding tissues and mediate these processes in response. The changes in intestinal tube vascularization induced by the movement of the food bowl, and the consequent pH changes that show an anisotropy in the thickness of the intestinal tube wall, have led to the identification of a pattern of intestinal tube development based on telocytes’ ability to communicate and modulate surrounding cell functions. In the construction of the theoretical model, given the predictable occurrence of colic in the infant, the two-layer arrangement of the nerve plexuses associated with the intestinal tube was considered to be incompletely adapted to the motility required with a diversified diet. There is resulting evidence of possible therapeutic targets for diseases associated with changes in local nerve tissue development.https://www.mdpi.com/1422-0067/23/13/7017telocytesinfant colicinflammatory bowel diseasesCrohn’s diseaseulcerative colitisirritable bowel syndrome |
| spellingShingle | Daniel Dumitru Banciu Dragoș Crețoiu Sanda Maria Crețoiu Adela Banciu Daniel Popa Rodica David Cristian Stefan Berghea-Neamtu Calin Remus Cipaian Mihai Octavian Negrea Mihaela Gheonea Bogdan Neamtu Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review International Journal of Molecular Sciences telocytes infant colic inflammatory bowel diseases Crohn’s disease ulcerative colitis irritable bowel syndrome |
| title | Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review |
| title_full | Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review |
| title_fullStr | Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review |
| title_full_unstemmed | Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review |
| title_short | Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review |
| title_sort | telocytes role in modulating gut motility function and development medical hypotheses and literature review |
| topic | telocytes infant colic inflammatory bowel diseases Crohn’s disease ulcerative colitis irritable bowel syndrome |
| url | https://www.mdpi.com/1422-0067/23/13/7017 |
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