Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types

Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types

Abstract Prioritizing disease-critical cell types by integrating genome-wide association studies (GWAS) with functional data is a fundamental goal. Single-cell chromatin accessibility (scATAC-seq) and gene expression (scRNA-seq) have characterized cell types at high resolution, and studies integrati...

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Bibliographic Details
Main Authors: Samuel S. Kim, Buu Truong, Karthik Jagadeesh, Kushal K. Dey, Amber Z. Shen, Soumya Raychaudhuri, Manolis Kellis, Alkes L. Price
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44742-0

Internet

https://doi.org/10.1038/s41467-024-44742-0

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