Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study
Patients with ovarian cancer (OC) often experience anxiety, depression and fear of progression (FOP); however, it is unclear whether surgical complexity has a role to play. We investigated the prevalence of anxiety, depression and FOP at 12 months post-cytoreductive surgery and investigated associat...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/1/75 |
| _version_ | 1797359082586243072 |
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| author | Aarti Lakhiani Carole Cummins Satyam Kumar Joanna Long Vivek Arora Janos Balega Tim Broadhead Timothy Duncan Richard Edmondson Christina Fotopoulou Rosalind Glasspool Desiree Kolomainen Ranjit Manchanda Orla McNally Jo Morrison Asima Mukhopadhyay Raj Naik Nick Wood Sudha Sundar |
| author_facet | Aarti Lakhiani Carole Cummins Satyam Kumar Joanna Long Vivek Arora Janos Balega Tim Broadhead Timothy Duncan Richard Edmondson Christina Fotopoulou Rosalind Glasspool Desiree Kolomainen Ranjit Manchanda Orla McNally Jo Morrison Asima Mukhopadhyay Raj Naik Nick Wood Sudha Sundar |
| author_sort | Aarti Lakhiani |
| collection | DOAJ |
| description | Patients with ovarian cancer (OC) often experience anxiety, depression and fear of progression (FOP); however, it is unclear whether surgical complexity has a role to play. We investigated the prevalence of anxiety, depression and FOP at 12 months post-cytoreductive surgery and investigated associations with surgical complexity, patient (age, ethnicity, performance status, BMI) and tumour (stage, disease load) factors. One hundred and forty-one patients with FIGO Stage III–IV OC, who did not have disease progression at 12 months post-surgery, completed the Hospital Anxiety and Depression Scale and FOP short-form questionnaire. Patients underwent surgery with low (40.4%), intermediate (31.2%) and high (28.4%) surgical complexity scores. At 12 months post-surgery, 99 of 141 (70%) patients with advanced OC undergoing surgery experienced clinically significant anxiety, 21 of 141 (14.9%) patients experienced moderate to severe depression and 37 of 140 (26.4%) experienced dysfunctional FOP. No associations were identified between the three different surgical complexity groups with regards to anxiety, depression or FOP scores. Unsurprisingly, given the natural history of the disease, most patients with OC suffer from anxiety, depression and fear of progression after completion of first-line cancer treatment. Surgical complexity at the time of surgery is not associated with a deleterious impact on anxiety, depression or FOP for patients with OC. Patients with OC experience a profound mental health impact and should be offered mental health support throughout their cancer journey. |
| first_indexed | 2024-03-08T15:10:30Z |
| format | Article |
| id | doaj.art-8529c957e4ca4f928221dca51c5645c0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T15:10:30Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8529c957e4ca4f928221dca51c5645c02024-01-10T14:52:31ZengMDPI AGCancers2072-66942023-12-011617510.3390/cancers16010075Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre StudyAarti Lakhiani0Carole Cummins1Satyam Kumar2Joanna Long3Vivek Arora4Janos Balega5Tim Broadhead6Timothy Duncan7Richard Edmondson8Christina Fotopoulou9Rosalind Glasspool10Desiree Kolomainen11Ranjit Manchanda12Orla McNally13Jo Morrison14Asima Mukhopadhyay15Raj Naik16Nick Wood17Sudha Sundar18Institute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UKInstitute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UKUniversity Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UKInstitute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UKSchool of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, AustraliaPan-Birmingham Gynaecological Cancer Centre, City Hospital, Birmingham B18 7QH, UKLeeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UKNorfolk & Norwich University Hospital, Norwich NR4 7UY, UKDivision of Cancer Services, University of Manchester, Manchester M13 9PL, UKDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UKBeatson West of Scotland Cancer Centre, NHS Greater Glasgow and Clyde and School of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UKKings College NHS Foundation Trust, London W1W 5DT, UKWolfson Institute of Population Health, Queen Mary University of London, London EC1M 6BQ, UKPeter MacCallum Cancer Centre, Melbourne, VIC 3052, AustraliaMusgrove Park Hospital, Somerset NHS Foundation Trust, Taunton TA1 5DA, UKKolkata Gynecological Oncology Trials and Translational Research Group, Kolkata 700156, IndiaNorthern Gynaecological Oncology Centre, Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust, Gateshead NE9 6SX, UKLancashire Teaching Hospitals NHS Foundation Trust, Preston PR2 9HT, UKPan-Birmingham Gynaecological Cancer Centre, City Hospital, Birmingham B18 7QH, UKPatients with ovarian cancer (OC) often experience anxiety, depression and fear of progression (FOP); however, it is unclear whether surgical complexity has a role to play. We investigated the prevalence of anxiety, depression and FOP at 12 months post-cytoreductive surgery and investigated associations with surgical complexity, patient (age, ethnicity, performance status, BMI) and tumour (stage, disease load) factors. One hundred and forty-one patients with FIGO Stage III–IV OC, who did not have disease progression at 12 months post-surgery, completed the Hospital Anxiety and Depression Scale and FOP short-form questionnaire. Patients underwent surgery with low (40.4%), intermediate (31.2%) and high (28.4%) surgical complexity scores. At 12 months post-surgery, 99 of 141 (70%) patients with advanced OC undergoing surgery experienced clinically significant anxiety, 21 of 141 (14.9%) patients experienced moderate to severe depression and 37 of 140 (26.4%) experienced dysfunctional FOP. No associations were identified between the three different surgical complexity groups with regards to anxiety, depression or FOP scores. Unsurprisingly, given the natural history of the disease, most patients with OC suffer from anxiety, depression and fear of progression after completion of first-line cancer treatment. Surgical complexity at the time of surgery is not associated with a deleterious impact on anxiety, depression or FOP for patients with OC. Patients with OC experience a profound mental health impact and should be offered mental health support throughout their cancer journey.https://www.mdpi.com/2072-6694/16/1/75ovarian cancerquality of lifeanxietydepressionfear of progression |
| spellingShingle | Aarti Lakhiani Carole Cummins Satyam Kumar Joanna Long Vivek Arora Janos Balega Tim Broadhead Timothy Duncan Richard Edmondson Christina Fotopoulou Rosalind Glasspool Desiree Kolomainen Ranjit Manchanda Orla McNally Jo Morrison Asima Mukhopadhyay Raj Naik Nick Wood Sudha Sundar Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study Cancers ovarian cancer quality of life anxiety depression fear of progression |
| title | Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study |
| title_full | Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study |
| title_fullStr | Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study |
| title_full_unstemmed | Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study |
| title_short | Analysis of Anxiety, Depression and Fear of Progression at 12 Months Post-Cytoreductive Surgery in the SOCQER-2 (Surgery in Ovarian Cancer—Quality of Life Evaluation Research) Prospective, International, Multicentre Study |
| title_sort | analysis of anxiety depression and fear of progression at 12 months post cytoreductive surgery in the socqer 2 surgery in ovarian cancer quality of life evaluation research prospective international multicentre study |
| topic | ovarian cancer quality of life anxiety depression fear of progression |
| url | https://www.mdpi.com/2072-6694/16/1/75 |
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