Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes
<p>Abstract</p> <p>Background</p> <p>This study aimed to analyze the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes of bacterial brain abscess in patients with nasopharyngeal carcinoma (NPC) following radiotherapy.</p> <...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2334/12/204 |
| _version_ | 1811245977203376128 |
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| author | Fang Peng-Hsiang Lin Wei-Che Tsai Nai-Wen Chang Wen-Neng Huang Chi-Ren Chang Hsueh-Wen Huang Tai-Lin Lin Hsin-Ching Lin Yu-Jun Cheng Ben-Chung Su Ben Kung Chia-Te Wang Hung-Chen Lu Cheng-Hsien |
| author_facet | Fang Peng-Hsiang Lin Wei-Che Tsai Nai-Wen Chang Wen-Neng Huang Chi-Ren Chang Hsueh-Wen Huang Tai-Lin Lin Hsin-Ching Lin Yu-Jun Cheng Ben-Chung Su Ben Kung Chia-Te Wang Hung-Chen Lu Cheng-Hsien |
| author_sort | Fang Peng-Hsiang |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study aimed to analyze the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes of bacterial brain abscess in patients with nasopharyngeal carcinoma (NPC) following radiotherapy.</p> <p>Methods</p> <p>NPC patients with bacterial brain abscess were evaluated. Their clinical data were collected over a 22-year period. For comparison, the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes between NPC and non-NPC patients were analyzed.</p> <p>Results</p> <p>NPC accounted for 5.7% (12/210) of the predisposing factors, with Viridans streptococci and <it>Staphylococcus aureus</it> as the two most common causative pathogens. Significant statistical analysis between the two groups (NPC and non-NPC patients) included chronic otitis media (COM) as the underlying disease, post-radiation necrosis by neuro-imaging, and the temporal lobe as the most common site of brain abscesses. The fatality rate in patients with and without NPC was 16.7% and 20.7%, respectively.</p> <p>Conclusions</p> <p>NPC patients with bacterial brain abscess frequently have COM as the underlying disease. Neuro-imaging often reveals both post-radiation necrosis and the temporal lobe as the most common site of brain abscesses, the diagnosis of which is not always a straightforward process. Radiation necrosis can mimic brain abscess on neuro-imaging and pose significant diagnostic challenges. Early diagnosis and treatment is essential for survival.</p> |
| first_indexed | 2024-04-12T14:47:21Z |
| format | Article |
| id | doaj.art-852a26d6744344acb0d54e1e156db1e8 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T14:47:21Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-852a26d6744344acb0d54e1e156db1e82022-12-22T03:28:36ZengBMCBMC Infectious Diseases1471-23342012-09-0112120410.1186/1471-2334-12-204Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomesFang Peng-HsiangLin Wei-CheTsai Nai-WenChang Wen-NengHuang Chi-RenChang Hsueh-WenHuang Tai-LinLin Hsin-ChingLin Yu-JunCheng Ben-ChungSu BenKung Chia-TeWang Hung-ChenLu Cheng-Hsien<p>Abstract</p> <p>Background</p> <p>This study aimed to analyze the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes of bacterial brain abscess in patients with nasopharyngeal carcinoma (NPC) following radiotherapy.</p> <p>Methods</p> <p>NPC patients with bacterial brain abscess were evaluated. Their clinical data were collected over a 22-year period. For comparison, the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes between NPC and non-NPC patients were analyzed.</p> <p>Results</p> <p>NPC accounted for 5.7% (12/210) of the predisposing factors, with Viridans streptococci and <it>Staphylococcus aureus</it> as the two most common causative pathogens. Significant statistical analysis between the two groups (NPC and non-NPC patients) included chronic otitis media (COM) as the underlying disease, post-radiation necrosis by neuro-imaging, and the temporal lobe as the most common site of brain abscesses. The fatality rate in patients with and without NPC was 16.7% and 20.7%, respectively.</p> <p>Conclusions</p> <p>NPC patients with bacterial brain abscess frequently have COM as the underlying disease. Neuro-imaging often reveals both post-radiation necrosis and the temporal lobe as the most common site of brain abscesses, the diagnosis of which is not always a straightforward process. Radiation necrosis can mimic brain abscess on neuro-imaging and pose significant diagnostic challenges. Early diagnosis and treatment is essential for survival.</p>http://www.biomedcentral.com/1471-2334/12/204Bacterial brain abscessNasopharyngeal carcinomaTherapeutic outcome |
| spellingShingle | Fang Peng-Hsiang Lin Wei-Che Tsai Nai-Wen Chang Wen-Neng Huang Chi-Ren Chang Hsueh-Wen Huang Tai-Lin Lin Hsin-Ching Lin Yu-Jun Cheng Ben-Chung Su Ben Kung Chia-Te Wang Hung-Chen Lu Cheng-Hsien Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes BMC Infectious Diseases Bacterial brain abscess Nasopharyngeal carcinoma Therapeutic outcome |
| title | Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes |
| title_full | Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes |
| title_fullStr | Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes |
| title_full_unstemmed | Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes |
| title_short | Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes |
| title_sort | bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy microbiology clinical features and therapeutic outcomes |
| topic | Bacterial brain abscess Nasopharyngeal carcinoma Therapeutic outcome |
| url | http://www.biomedcentral.com/1471-2334/12/204 |
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