Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix, play an important role in tissue remodeling associated with various physiological processes such as morphogenesis, angiogenesis, and tissue repair, as well as pathologi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-06-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/6/3/1298 |
| _version_ | 1797707668121452544 |
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| author | Yixuan Gong Uma D. Chippada-Venkata William K. Oh |
| author_facet | Yixuan Gong Uma D. Chippada-Venkata William K. Oh |
| author_sort | Yixuan Gong |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix, play an important role in tissue remodeling associated with various physiological processes such as morphogenesis, angiogenesis, and tissue repair, as well as pathological processes including cirrhosis, arthritis and cancer. The MMPs are well established as mediators of tumor invasion and metastasis by breaking down connective tissue barriers. Although there has been a vast amount of literature on the role of MMPs in invasion, metastasis and angiogenesis of various cancers, the role of these endopeptidases in prostate cancer progression has not been systematically reviewed. This overview summarizes findings on the tissue and blood expression of MMPs, their function, regulation and prognostic implication in human prostate cancer, with a focus on MMP-2, -7, -9, MT1-MMP and tissue inhibitor of metalloproteinase 1 (TIMP-1). This review also summarizes the efficacy and failure of early-generation matrix metalloproteinase inhibitors (MMPIs) in the treatment of metastatic prostate cancer and highlights the lessons and challenges for next generation MMPIs. |
| first_indexed | 2024-03-12T06:09:43Z |
| format | Article |
| id | doaj.art-852c52ada9764292adea3a4ebe7a164b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:09:43Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-852c52ada9764292adea3a4ebe7a164b2023-09-03T03:07:49ZengMDPI AGCancers2072-66942014-06-01631298132710.3390/cancers6031298cancers6031298Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer ProgressionYixuan Gong0Uma D. Chippada-Venkata1William K. Oh2Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAMatrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix, play an important role in tissue remodeling associated with various physiological processes such as morphogenesis, angiogenesis, and tissue repair, as well as pathological processes including cirrhosis, arthritis and cancer. The MMPs are well established as mediators of tumor invasion and metastasis by breaking down connective tissue barriers. Although there has been a vast amount of literature on the role of MMPs in invasion, metastasis and angiogenesis of various cancers, the role of these endopeptidases in prostate cancer progression has not been systematically reviewed. This overview summarizes findings on the tissue and blood expression of MMPs, their function, regulation and prognostic implication in human prostate cancer, with a focus on MMP-2, -7, -9, MT1-MMP and tissue inhibitor of metalloproteinase 1 (TIMP-1). This review also summarizes the efficacy and failure of early-generation matrix metalloproteinase inhibitors (MMPIs) in the treatment of metastatic prostate cancer and highlights the lessons and challenges for next generation MMPIs.http://www.mdpi.com/2072-6694/6/3/1298MMPTIMPprostate cancer |
| spellingShingle | Yixuan Gong Uma D. Chippada-Venkata William K. Oh Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression Cancers MMP TIMP prostate cancer |
| title | Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression |
| title_full | Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression |
| title_fullStr | Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression |
| title_full_unstemmed | Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression |
| title_short | Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression |
| title_sort | roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression |
| topic | MMP TIMP prostate cancer |
| url | http://www.mdpi.com/2072-6694/6/3/1298 |
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