Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution
Since the evolution of the aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as a major source of cellular damage while also...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/13/3/312 |
| _version_ | 1797242285982744576 |
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| author | Yuhang Hong Alessandra Boiti Daniela Vallone Nicholas S. Foulkes |
| author_facet | Yuhang Hong Alessandra Boiti Daniela Vallone Nicholas S. Foulkes |
| author_sort | Yuhang Hong |
| collection | DOAJ |
| description | Since the evolution of the aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as a major source of cellular damage while also functioning as important signaling molecules in various biological processes. Our understanding of ROS homeostasis and ROS-mediated cellular signaling pathways has presumed that they are ancient and highly conserved mechanisms shared by most organisms. However, emerging evidence highlights the complexity and plasticity of ROS signaling, particularly in animals that have evolved in extreme environments. In this review, we focus on ROS generation, antioxidative systems and the main signaling pathways that are influenced by ROS. In addition, we discuss ROS’s responsive transcription regulation and how it may have been shaped over the course of evolution. |
| first_indexed | 2024-04-24T18:36:48Z |
| format | Article |
| id | doaj.art-852ce77d516e45628560691f6f719f77 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-04-24T18:36:48Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-852ce77d516e45628560691f6f719f772024-03-27T13:18:32ZengMDPI AGAntioxidants2076-39212024-03-0113331210.3390/antiox13030312Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and EvolutionYuhang Hong0Alessandra Boiti1Daniela Vallone2Nicholas S. Foulkes3Institute of Biological and Chemical Systems, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, GermanyInstitute of Biological and Chemical Systems, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, GermanyInstitute of Biological and Chemical Systems, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, GermanyInstitute of Biological and Chemical Systems, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, GermanySince the evolution of the aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as a major source of cellular damage while also functioning as important signaling molecules in various biological processes. Our understanding of ROS homeostasis and ROS-mediated cellular signaling pathways has presumed that they are ancient and highly conserved mechanisms shared by most organisms. However, emerging evidence highlights the complexity and plasticity of ROS signaling, particularly in animals that have evolved in extreme environments. In this review, we focus on ROS generation, antioxidative systems and the main signaling pathways that are influenced by ROS. In addition, we discuss ROS’s responsive transcription regulation and how it may have been shaped over the course of evolution.https://www.mdpi.com/2076-3921/13/3/312reactive oxygen speciescellular signalingDNA repairtranscriptional regulationvertebrate evolution |
| spellingShingle | Yuhang Hong Alessandra Boiti Daniela Vallone Nicholas S. Foulkes Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution Antioxidants reactive oxygen species cellular signaling DNA repair transcriptional regulation vertebrate evolution |
| title | Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution |
| title_full | Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution |
| title_fullStr | Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution |
| title_full_unstemmed | Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution |
| title_short | Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution |
| title_sort | reactive oxygen species signaling and oxidative stress transcriptional regulation and evolution |
| topic | reactive oxygen species cellular signaling DNA repair transcriptional regulation vertebrate evolution |
| url | https://www.mdpi.com/2076-3921/13/3/312 |
| work_keys_str_mv | AT yuhanghong reactiveoxygenspeciessignalingandoxidativestresstranscriptionalregulationandevolution AT alessandraboiti reactiveoxygenspeciessignalingandoxidativestresstranscriptionalregulationandevolution AT danielavallone reactiveoxygenspeciessignalingandoxidativestresstranscriptionalregulationandevolution AT nicholassfoulkes reactiveoxygenspeciessignalingandoxidativestresstranscriptionalregulationandevolution |