Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer
Numerous biologic approaches are being investigated as anti-cancer therapies in an attempt to induce tumor regression while circumventing the toxic side effects associated with standard chemo- or radiotherapies. Among these, tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has shown p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/1/603/ |
| _version_ | 1797722141407313920 |
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| author | Lyse A. Norian Britnie R. James Thomas S. Griffith |
| author_facet | Lyse A. Norian Britnie R. James Thomas S. Griffith |
| author_sort | Lyse A. Norian |
| collection | DOAJ |
| description | Numerous biologic approaches are being investigated as anti-cancer therapies in an attempt to induce tumor regression while circumventing the toxic side effects associated with standard chemo- or radiotherapies. Among these, tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has shown particular promise in pre-clinical and early clinical trials, due to its preferential ability to induce apoptotic cell death in cancer cells and its minimal toxicity. One limitation of TRAIL use is the fact that many tumor types display an inherent resistance to TRAIL-induced apoptosis. To circumvent this problem, researchers have explored a number of strategies to optimize TRAIL delivery and to improve its efficacy via co-administration with other anti-cancer agents. In this review, we will focus on TRAIL-based gene therapy approaches for the treatment of malignancies. We will discuss the main viral vectors that are being used for TRAIL gene therapy and the strategies that are currently being attempted to improve the efficacy of TRAIL as an anti-cancer therapeutic. |
| first_indexed | 2024-03-12T09:44:13Z |
| format | Article |
| id | doaj.art-852d8032dfb04099876f00c75ac4f697 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:44:13Z |
| publishDate | 2011-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-852d8032dfb04099876f00c75ac4f6972023-09-02T13:01:17ZengMDPI AGCancers2072-66942011-02-013160362010.3390/cancers3010603Advances in Viral Vector-Based TRAIL Gene Therapy for CancerLyse A. NorianBritnie R. JamesThomas S. GriffithNumerous biologic approaches are being investigated as anti-cancer therapies in an attempt to induce tumor regression while circumventing the toxic side effects associated with standard chemo- or radiotherapies. Among these, tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has shown particular promise in pre-clinical and early clinical trials, due to its preferential ability to induce apoptotic cell death in cancer cells and its minimal toxicity. One limitation of TRAIL use is the fact that many tumor types display an inherent resistance to TRAIL-induced apoptosis. To circumvent this problem, researchers have explored a number of strategies to optimize TRAIL delivery and to improve its efficacy via co-administration with other anti-cancer agents. In this review, we will focus on TRAIL-based gene therapy approaches for the treatment of malignancies. We will discuss the main viral vectors that are being used for TRAIL gene therapy and the strategies that are currently being attempted to improve the efficacy of TRAIL as an anti-cancer therapeutic.http://www.mdpi.com/2072-6694/3/1/603/TRAILgene therapyviral vectorscancerapoptosis |
| spellingShingle | Lyse A. Norian Britnie R. James Thomas S. Griffith Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer Cancers TRAIL gene therapy viral vectors cancer apoptosis |
| title | Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer |
| title_full | Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer |
| title_fullStr | Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer |
| title_full_unstemmed | Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer |
| title_short | Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer |
| title_sort | advances in viral vector based trail gene therapy for cancer |
| topic | TRAIL gene therapy viral vectors cancer apoptosis |
| url | http://www.mdpi.com/2072-6694/3/1/603/ |
| work_keys_str_mv | AT lyseanorian advancesinviralvectorbasedtrailgenetherapyforcancer AT britnierjames advancesinviralvectorbasedtrailgenetherapyforcancer AT thomassgriffith advancesinviralvectorbasedtrailgenetherapyforcancer |