Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report
Abstract Background Scleredema adultorum of Buschke is a rare disease characterized by firm and non-pitting edema of the skin. The condition is rare with unknown etiology. Diagnosis is made on the basis of clinical findings and skin biopsy. Case presentation Here, we describe a 14-year-old Iranian g...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-024-04427-0 |
| _version_ | 1797274518132097024 |
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| author | Mehran Pournazari Dena Mohamadzadeh Shirin Assar Mazaher Ramezani |
| author_facet | Mehran Pournazari Dena Mohamadzadeh Shirin Assar Mazaher Ramezani |
| author_sort | Mehran Pournazari |
| collection | DOAJ |
| description | Abstract Background Scleredema adultorum of Buschke is a rare disease characterized by firm and non-pitting edema of the skin. The condition is rare with unknown etiology. Diagnosis is made on the basis of clinical findings and skin biopsy. Case presentation Here, we describe a 14-year-old Iranian girl presenting with non-pitting edema and woody thickening of the skin that progressed within a month. She was evaluated for possible underlying malignancy or connective tissue disorders, which were excluded by multiple laboratory workups. She underwent a skin biopsy which confirmed the diagnosis of scleredema, and she was successfully treated with intravenous immunoglobulin and mycophenolate mofetil. Conclusion While scleredema adultorum of Buschke is a rare disease with no definite treatment, our effort through this report was to highlight the possible benefits of treatment by intravenous immunoglobulin and mycophenolate mofetil. |
| first_indexed | 2024-03-07T14:59:32Z |
| format | Article |
| id | doaj.art-852e43609cb741a1a00837ecb9a994f5 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-07T14:59:32Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-852e43609cb741a1a00837ecb9a994f52024-03-05T19:14:51ZengBMCJournal of Medical Case Reports1752-19472024-02-011811410.1186/s13256-024-04427-0Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case reportMehran Pournazari0Dena Mohamadzadeh1Shirin Assar2Mazaher Ramezani3Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical SciencesMolecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical SciencesAbstract Background Scleredema adultorum of Buschke is a rare disease characterized by firm and non-pitting edema of the skin. The condition is rare with unknown etiology. Diagnosis is made on the basis of clinical findings and skin biopsy. Case presentation Here, we describe a 14-year-old Iranian girl presenting with non-pitting edema and woody thickening of the skin that progressed within a month. She was evaluated for possible underlying malignancy or connective tissue disorders, which were excluded by multiple laboratory workups. She underwent a skin biopsy which confirmed the diagnosis of scleredema, and she was successfully treated with intravenous immunoglobulin and mycophenolate mofetil. Conclusion While scleredema adultorum of Buschke is a rare disease with no definite treatment, our effort through this report was to highlight the possible benefits of treatment by intravenous immunoglobulin and mycophenolate mofetil.https://doi.org/10.1186/s13256-024-04427-0Scleredema adultorum of BuschkeSkin thickeningIntravenous immunoglobulinMycophenolate mofetil |
| spellingShingle | Mehran Pournazari Dena Mohamadzadeh Shirin Assar Mazaher Ramezani Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report Journal of Medical Case Reports Scleredema adultorum of Buschke Skin thickening Intravenous immunoglobulin Mycophenolate mofetil |
| title | Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report |
| title_full | Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report |
| title_fullStr | Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report |
| title_full_unstemmed | Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report |
| title_short | Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report |
| title_sort | treatment of scleredema adultorum of buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14 year old girl a case report |
| topic | Scleredema adultorum of Buschke Skin thickening Intravenous immunoglobulin Mycophenolate mofetil |
| url | https://doi.org/10.1186/s13256-024-04427-0 |
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