The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension
BackgroundAdverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently reported beneficial results in BP control in patients with TRH adopting an innovative approach, defined as therapeutic concordance, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1137706/full |
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| author | Valentina Trimarco Maria Virginia Manzi Raffaele Izzo Pasquale Mone Pasquale Mone Maria Lembo Daniela Pacella Giovanni Esposito Angela Falco Carmine Morisco Carmine Morisco Paola Gallo Gaetano Santulli Gaetano Santulli Gaetano Santulli Gaetano Santulli Bruno Trimarco Bruno Trimarco |
| author_facet | Valentina Trimarco Maria Virginia Manzi Raffaele Izzo Pasquale Mone Pasquale Mone Maria Lembo Daniela Pacella Giovanni Esposito Angela Falco Carmine Morisco Carmine Morisco Paola Gallo Gaetano Santulli Gaetano Santulli Gaetano Santulli Gaetano Santulli Bruno Trimarco Bruno Trimarco |
| author_sort | Valentina Trimarco |
| collection | DOAJ |
| description | BackgroundAdverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently reported beneficial results in BP control in patients with TRH adopting an innovative approach, defined as therapeutic concordance, in which trained physicians and pharmacists reach a concordance with patients to make them more involved in the therapeutic decision-making process.MethodsThe main scope of this study was to investigate whether the therapeutic concordance approach could lead to a reduction in ADR occurrence in TRH patients. The study was performed in a large population of hypertensive subjects of the Campania Salute Network in Italy (ClinicalTrials.gov Identifier: NCT02211365).ResultsWe enrolled 4,943 patients who were firstly followed-up for 77.64 ± 34.44 months, allowing us to identify 564 subjects with TRH. Then, 282 of these patients agreed to participate in an investigation to test the impact of the therapeutic concordance approach on ADRs. At the end of this investigation, which had a follow-up of 91.91 ± 54.7 months, 213 patients (75.5%) remained uncontrolled while 69 patients (24.5%, p < 0.0001) reached an optimal BP control. Strikingly, during the first follow-up, patients had complained of a total of 194 ADRs, with an occurrence rate of 68.1% and the therapeutic concordance approach significantly reduced ADRs to 72 (25.5%).ConclusionOur findings indicate that the therapeutic concordance approach significantly reduces ADRs in TRH patients. |
| first_indexed | 2024-04-09T14:17:29Z |
| format | Article |
| id | doaj.art-852ede3e66e545eab2b1620b622378f1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T14:17:29Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-852ede3e66e545eab2b1620b622378f12023-05-05T05:56:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-05-011010.3389/fcvm.2023.11377061137706The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertensionValentina Trimarco0Maria Virginia Manzi1Raffaele Izzo2Pasquale Mone3Pasquale Mone4Maria Lembo5Daniela Pacella6Giovanni Esposito7Angela Falco8Carmine Morisco9Carmine Morisco10Paola Gallo11Gaetano Santulli12Gaetano Santulli13Gaetano Santulli14Gaetano Santulli15Bruno Trimarco16Bruno Trimarco17Department of Neuroscience, Reproductive Sciences, and Dentistry, “Federico II” University, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York, NY, USAInternational Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Public Health, “Federico II” University, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences, and Dentistry, “Federico II” University, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyInternational Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York, NY, USAInternational Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples, ItalyDepartment of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Einstein Institute for Neuroimmunology and Inflammation (INI), Albert Einstein College of Medicine, New York, NY, USADepartment of Advanced Biomedical Sciences,“Federico II” University, Naples, ItalyInternational Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples, ItalyBackgroundAdverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently reported beneficial results in BP control in patients with TRH adopting an innovative approach, defined as therapeutic concordance, in which trained physicians and pharmacists reach a concordance with patients to make them more involved in the therapeutic decision-making process.MethodsThe main scope of this study was to investigate whether the therapeutic concordance approach could lead to a reduction in ADR occurrence in TRH patients. The study was performed in a large population of hypertensive subjects of the Campania Salute Network in Italy (ClinicalTrials.gov Identifier: NCT02211365).ResultsWe enrolled 4,943 patients who were firstly followed-up for 77.64 ± 34.44 months, allowing us to identify 564 subjects with TRH. Then, 282 of these patients agreed to participate in an investigation to test the impact of the therapeutic concordance approach on ADRs. At the end of this investigation, which had a follow-up of 91.91 ± 54.7 months, 213 patients (75.5%) remained uncontrolled while 69 patients (24.5%, p < 0.0001) reached an optimal BP control. Strikingly, during the first follow-up, patients had complained of a total of 194 ADRs, with an occurrence rate of 68.1% and the therapeutic concordance approach significantly reduced ADRs to 72 (25.5%).ConclusionOur findings indicate that the therapeutic concordance approach significantly reduces ADRs in TRH patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1137706/fulladherenceadverse drug reactionsblood pressurecomplianceconcordancehypertension |
| spellingShingle | Valentina Trimarco Maria Virginia Manzi Raffaele Izzo Pasquale Mone Pasquale Mone Maria Lembo Daniela Pacella Giovanni Esposito Angela Falco Carmine Morisco Carmine Morisco Paola Gallo Gaetano Santulli Gaetano Santulli Gaetano Santulli Gaetano Santulli Bruno Trimarco Bruno Trimarco The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension Frontiers in Cardiovascular Medicine adherence adverse drug reactions blood pressure compliance concordance hypertension |
| title | The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| title_full | The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| title_fullStr | The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| title_full_unstemmed | The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| title_short | The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| title_sort | therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension |
| topic | adherence adverse drug reactions blood pressure compliance concordance hypertension |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1137706/full |
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