MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA
Ting Yang,1 Fang He,1 Mingxiang Zhang,2 Li Ai,1 Meng He,3 Xin Liu,3 Yongxia Li1 1Department of Respiratory, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of China; 2Department of Cardiothoracic Surgery, Children’s Hospital affiliated to Kunming Medic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/mir-142-3p-as-an-indicator-of-osa-severity-predicts-prognosis-in-lung--peer-reviewed-fulltext-article-NSS |
| _version_ | 1797984328534196224 |
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| author | Yang T He F Zhang M Ai L He M Liu X Li Y |
| author_facet | Yang T He F Zhang M Ai L He M Liu X Li Y |
| author_sort | Yang T |
| collection | DOAJ |
| description | Ting Yang,1 Fang He,1 Mingxiang Zhang,2 Li Ai,1 Meng He,3 Xin Liu,3 Yongxia Li1 1Department of Respiratory, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of China; 2Department of Cardiothoracic Surgery, Children’s Hospital affiliated to Kunming Medical University, Yunnan, 650000, People’s Republic of China; 3Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of ChinaCorrespondence: Yongxia Li, Department of Respiratory, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of China, Email liyongxia@kmmu.edu.cnPurpose: The aim was to explore the correlation between Obstructive sleep apnea (OSA) and Lung adenocarcinoma malignant prognosis and evaluate the miR-142-3p was used as an OSA severity indicator to predict the prognosis of Lung adenocarcinoma patients.Methods: This study comprised of 21 diagnosed lung adenocarcinoma patients with or without OSA. The sleep-related variables and tumor pathology were recorded. Hypoxia-inducible factor-1α (HIF1α) and ki67 expression were analyzed by immunohistochemistry in tumor samples. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the level of miR-142-3p.Results: Lung adenocarcinoma with OSA showed higher apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and the lower lowest pulse oxygen saturation (LSPO2) compared to Lung adenocarcinoma without OSA (P< 0.05), and patients with severer OSA have an advanced TNM stage (P=0.004) and metastasis rate (p=0.032). In addition, OSA may down-regulate the miR-142-3p expression in patients with Lung adenocarcinoma, and the patients with low miR-142-3p expression exhibited severe OSA. MiR-142-3p levels significantly decreased in the advanced TNM stage (p=0.015), and the expression of miR-142-3p was negatively associated with AHI (r= − 0.505, p=0.020), ODI (r= − 0.513, p=0.017).Conclusion: OSA severity may increase Lung adenocarcinoma malignant prognosis. OSA may down-regulate the expression of miR-42-3p. The expression of miR-142-3p was inversely correlated with AHI and ODI as a surrogate of OSA severity. Additionally, the low miR-142-3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients.Keywords: obstructive sleep apnea, lung adenocarcinoma, miR-142-3p, HIF1α, prognosis |
| first_indexed | 2024-04-11T07:00:10Z |
| format | Article |
| id | doaj.art-852f8f111d30450b943e78b9ef87af42 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-04-11T07:00:10Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-852f8f111d30450b943e78b9ef87af422022-12-22T04:38:48ZengDove Medical PressNature and Science of Sleep1179-16082022-11-01Volume 142047205479556MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSAYang THe FZhang MAi LHe MLiu XLi YTing Yang,1 Fang He,1 Mingxiang Zhang,2 Li Ai,1 Meng He,3 Xin Liu,3 Yongxia Li1 1Department of Respiratory, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of China; 2Department of Cardiothoracic Surgery, Children’s Hospital affiliated to Kunming Medical University, Yunnan, 650000, People’s Republic of China; 3Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of ChinaCorrespondence: Yongxia Li, Department of Respiratory, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650000, People’s Republic of China, Email liyongxia@kmmu.edu.cnPurpose: The aim was to explore the correlation between Obstructive sleep apnea (OSA) and Lung adenocarcinoma malignant prognosis and evaluate the miR-142-3p was used as an OSA severity indicator to predict the prognosis of Lung adenocarcinoma patients.Methods: This study comprised of 21 diagnosed lung adenocarcinoma patients with or without OSA. The sleep-related variables and tumor pathology were recorded. Hypoxia-inducible factor-1α (HIF1α) and ki67 expression were analyzed by immunohistochemistry in tumor samples. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the level of miR-142-3p.Results: Lung adenocarcinoma with OSA showed higher apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and the lower lowest pulse oxygen saturation (LSPO2) compared to Lung adenocarcinoma without OSA (P< 0.05), and patients with severer OSA have an advanced TNM stage (P=0.004) and metastasis rate (p=0.032). In addition, OSA may down-regulate the miR-142-3p expression in patients with Lung adenocarcinoma, and the patients with low miR-142-3p expression exhibited severe OSA. MiR-142-3p levels significantly decreased in the advanced TNM stage (p=0.015), and the expression of miR-142-3p was negatively associated with AHI (r= − 0.505, p=0.020), ODI (r= − 0.513, p=0.017).Conclusion: OSA severity may increase Lung adenocarcinoma malignant prognosis. OSA may down-regulate the expression of miR-42-3p. The expression of miR-142-3p was inversely correlated with AHI and ODI as a surrogate of OSA severity. Additionally, the low miR-142-3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients.Keywords: obstructive sleep apnea, lung adenocarcinoma, miR-142-3p, HIF1α, prognosishttps://www.dovepress.com/mir-142-3p-as-an-indicator-of-osa-severity-predicts-prognosis-in-lung--peer-reviewed-fulltext-article-NSSobstructive sleep apnealung adenocarcinomamir-142-3phif1αprognosis |
| spellingShingle | Yang T He F Zhang M Ai L He M Liu X Li Y MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA Nature and Science of Sleep obstructive sleep apnea lung adenocarcinoma mir-142-3p hif1α prognosis |
| title | MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA |
| title_full | MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA |
| title_fullStr | MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA |
| title_full_unstemmed | MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA |
| title_short | MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA |
| title_sort | mir 142 3p as an indicator of osa severity predicts prognosis in lung adenocarcinoma with osa |
| topic | obstructive sleep apnea lung adenocarcinoma mir-142-3p hif1α prognosis |
| url | https://www.dovepress.com/mir-142-3p-as-an-indicator-of-osa-severity-predicts-prognosis-in-lung--peer-reviewed-fulltext-article-NSS |
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