Seroprevalence of IgG Antibodies against Rubella in Young Females in a Medical College in Chennai, India
Introduction: Rubella being a mild infection, rarely causes any complications in childhood, will cause adverse effects during pregnancy ranging from miscarriage to a child born with congenital rubella syndrome. Females of reproductive age group must be immune to rubella to prevent infection duri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15987/50699_CE(Ra1)_F(SS)_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Rubella being a mild infection, rarely causes any
complications in childhood, will cause adverse effects during
pregnancy ranging from miscarriage to a child born with
congenital rubella syndrome. Females of reproductive age group
must be immune to rubella to prevent infection during pregnancy.
Medical students and healthcare workers should have sufficient
immunity to rubella as there are increased chances of them getting
exposed to the infection. To estimate the immune status against
rubella, measurement of Immunoglobulin G (IgG) antibody titre
will be helpful.
Aim: To detect the level of IgG antibodies specific to rubella
in the sera of young female students in a Medical College in
Chennai, Tamil Nadu, India and to determine the proportion of
anti-rubella IgG seropositivity.
Materials and Methods: A cross-sectional study was conducted
at ESIC Medical College and PGIMSR, KK Nagar, Chennai, Tamil
Nadu, India, from July 2019 to August 2019. A total of 90 female
students of the age group 19-26 years were selected by random
sampling method. After obtaining informed consent, their blood
samples were collected. The IgG antibody titre in the serum was
estimated by indirect Enzyme Linked Immunosorbent Assay
(ELISA). Statistical analysis was done using Statistical Package
for the Social Sciences (SPSS) version 26.0.
Results: Based on the test results, 62 (68.9%) were immune,
25 (27.8%) were not immune, and 3 (3.3%) had indeterminate
results. No association was found between the age of the
participants and their immune status.
Conclusion: Through the present study, it can be concluded
that there was a low level of seropositivity of protective rubella
antibodies among females, particularly the medical students
who were the study population. |
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| ISSN: | 2249-782X 0973-709X |