PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD
Background. Oxidative stress plays an important role in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). Antioxidant trace elements as cofactors of antioxidant enzymes and metalloproteins are involved in this process. Zinc being an important antioxidant may have a positive effec...
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| Language: | English |
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Science and Innovation Center Publishing House
2023-02-01
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| Series: | Siberian Journal of Life Sciences and Agriculture |
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| Online Access: | http://discover-journal.ru/jour/index.php/sjlsa/article/view/742 |
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| author | Eugenia R. Nikonorova Alexandr A. Nikonorov Elizaveta V. Popova Eduard F. Agletdinov Anton I. Sinitskii Alexey A. Tinkov |
| author_facet | Eugenia R. Nikonorova Alexandr A. Nikonorov Elizaveta V. Popova Eduard F. Agletdinov Anton I. Sinitskii Alexey A. Tinkov |
| author_sort | Eugenia R. Nikonorova |
| collection | DOAJ |
| description | Background. Oxidative stress plays an important role in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). Antioxidant trace elements as cofactors of antioxidant enzymes and metalloproteins are involved in this process. Zinc being an important antioxidant may have a positive effect on the treatment of liver pathology. The study aimed to assess the effect of preventive zinc supplementation on MAFLD in rats.
Materials and Methods. A total of 26 three-month-old female Wistar rats were used in the present study. The activity of the antioxidant enzymes superoxide dismutase and catalase, some redox status markers, such as ceruloplasmin, oxidized tryptophan, dithyrosines, total thiols, carbonyls, TBARS, and uric acid were evaluated. Oxidative stress biomarkers were studied spectrophotometrically.
Results. MAFLD was accompanied by hyperuricemia and a decrease in serum dityrosines. The addition of Zn to the diet prevented the development of steatosis, decreased the level of oxidized tryptophan in the liver, and paradoxically caused hyperuricemia in the MAFLD model used. Zn supplementation had a positive effect on the prevention of MAFLD, had a little effect on redox status of animals but caused paradoxical hyperuricemia. Future studies are needed to establish the mechanisms of the Zn effect at the cellular level. |
| first_indexed | 2024-03-12T21:17:57Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2658-6649 2658-6657 |
| language | English |
| last_indexed | 2024-03-12T21:17:57Z |
| publishDate | 2023-02-01 |
| publisher | Science and Innovation Center Publishing House |
| record_format | Article |
| series | Siberian Journal of Life Sciences and Agriculture |
| spelling | doaj.art-85306bc80da1444f9fef12071721ded82023-07-29T03:42:29ZengScience and Innovation Center Publishing HouseSiberian Journal of Life Sciences and Agriculture2658-66492658-66572023-02-0115112314010.12731/2658-6649-2023-15-1-123-140742PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLDEugenia R. Nikonorova0Alexandr A. Nikonorov1Elizaveta V. Popova2Eduard F. Agletdinov3Anton I. Sinitskii4Alexey A. Tinkov5All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR)State Research Center of Dermatovenerology and CosmetologySt Joseph University in Tanzania; St. Joseph College of Health and Allied SciencesVector-BestSouth Ural State Medical UniversityYaroslavl State University; I.M. Sechenov First Moscow State Medical UniversityBackground. Oxidative stress plays an important role in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). Antioxidant trace elements as cofactors of antioxidant enzymes and metalloproteins are involved in this process. Zinc being an important antioxidant may have a positive effect on the treatment of liver pathology. The study aimed to assess the effect of preventive zinc supplementation on MAFLD in rats. Materials and Methods. A total of 26 three-month-old female Wistar rats were used in the present study. The activity of the antioxidant enzymes superoxide dismutase and catalase, some redox status markers, such as ceruloplasmin, oxidized tryptophan, dithyrosines, total thiols, carbonyls, TBARS, and uric acid were evaluated. Oxidative stress biomarkers were studied spectrophotometrically. Results. MAFLD was accompanied by hyperuricemia and a decrease in serum dityrosines. The addition of Zn to the diet prevented the development of steatosis, decreased the level of oxidized tryptophan in the liver, and paradoxically caused hyperuricemia in the MAFLD model used. Zn supplementation had a positive effect on the prevention of MAFLD, had a little effect on redox status of animals but caused paradoxical hyperuricemia. Future studies are needed to establish the mechanisms of the Zn effect at the cellular level.http://discover-journal.ru/jour/index.php/sjlsa/article/view/742mafldredox statusliver steatosiszincuric acid |
| spellingShingle | Eugenia R. Nikonorova Alexandr A. Nikonorov Elizaveta V. Popova Eduard F. Agletdinov Anton I. Sinitskii Alexey A. Tinkov PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD Siberian Journal of Life Sciences and Agriculture mafld redox status liver steatosis zinc uric acid |
| title | PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD |
| title_full | PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD |
| title_fullStr | PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD |
| title_full_unstemmed | PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD |
| title_short | PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD |
| title_sort | preventive zinc supplementation effect on redox status in rat model of mafld |
| topic | mafld redox status liver steatosis zinc uric acid |
| url | http://discover-journal.ru/jour/index.php/sjlsa/article/view/742 |
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