microRNA-mediated noise processing in cells: A fight or a game?
In the past decades, microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the always more sophisticated experimental techniques, the role of m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037019303824 |
| _version_ | 1818721756959997952 |
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| author | Elsi Ferro Chiara Enrico Bena Silvia Grigolon Carla Bosia |
| author_facet | Elsi Ferro Chiara Enrico Bena Silvia Grigolon Carla Bosia |
| author_sort | Elsi Ferro |
| collection | DOAJ |
| description | In the past decades, microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the always more sophisticated experimental techniques, the role of miRNAs as “noise processing units” has been further elucidated and two main ways of miRNA noise-control have emerged by combinations of theoretical and experimental studies. While on one side miRNAs were thought to buffer gene expression noise, it has recently been suggested that miRNAs could also increase the cell-to-cell variability of their targets. In this Mini Review, we focus on the role of miRNAs in molecular noise processing and on the advantages as well as current limitations of theoretical modelling. |
| first_indexed | 2024-12-17T20:43:48Z |
| format | Article |
| id | doaj.art-8531094a3144477fb21906a163275762 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-17T20:43:48Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-8531094a3144477fb21906a1632757622022-12-21T21:33:15ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-0118642649microRNA-mediated noise processing in cells: A fight or a game?Elsi Ferro0Chiara Enrico Bena1Silvia Grigolon2Carla Bosia3Italian Institute for Genomic Medicine, ItalyItalian Institute for Genomic Medicine, ItalyThe Francis Crick Institute, 1, Midland Road, London NW1 1AT, UK; Corresponding authors.Italian Institute for Genomic Medicine, Italy; Department of Applied Science and Technology, Politecnico di Torino, Italy; Corresponding authors.In the past decades, microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the always more sophisticated experimental techniques, the role of miRNAs as “noise processing units” has been further elucidated and two main ways of miRNA noise-control have emerged by combinations of theoretical and experimental studies. While on one side miRNAs were thought to buffer gene expression noise, it has recently been suggested that miRNAs could also increase the cell-to-cell variability of their targets. In this Mini Review, we focus on the role of miRNAs in molecular noise processing and on the advantages as well as current limitations of theoretical modelling.http://www.sciencedirect.com/science/article/pii/S2001037019303824 |
| spellingShingle | Elsi Ferro Chiara Enrico Bena Silvia Grigolon Carla Bosia microRNA-mediated noise processing in cells: A fight or a game? Computational and Structural Biotechnology Journal |
| title | microRNA-mediated noise processing in cells: A fight or a game? |
| title_full | microRNA-mediated noise processing in cells: A fight or a game? |
| title_fullStr | microRNA-mediated noise processing in cells: A fight or a game? |
| title_full_unstemmed | microRNA-mediated noise processing in cells: A fight or a game? |
| title_short | microRNA-mediated noise processing in cells: A fight or a game? |
| title_sort | microrna mediated noise processing in cells a fight or a game |
| url | http://www.sciencedirect.com/science/article/pii/S2001037019303824 |
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