Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL))
<p>An interim analysis of long-term treatment results for 202 patients with acute lymphoblastic leukemia (ALL), aged 15–60 years, received therapy according protocol ALL-2009 was shown. The basic principle of ALL-2009 was non-aggressive, but continued cytostatic exposure, as well as the reprod...
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| Language: | Russian |
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ABV-press
2015-01-01
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| Series: | Онкогематология |
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| Online Access: | http://oncohematology.abvpress.ru/index.php/ongm/article/view/118 |
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| author | E. N. Parovichnikova V. V. Troitskaya A. N. Sokolov Z. Kh. Akhmerzaeva L. A. Kuzmina L. P. Mendeleeva G. A. Klyasova S. K. Kravchenko Ye. O. Gribanova S. N. Bondarenko O. Yu. Baranova T. S. Kaporskaya T. V. Ryltsova A. S. Nizamutdinova T. P. Zagoskina Ye. Ye. Zinina O. S. Samoylova A. V. Klimovich Ye. A. Karyakina A. S. Yelufer’eva L. V. Gavrilova T. S. Konstantinova I. Yu. Toropova A. S. Pristupa N. A. Vopilina T. S. Tikunova O. P. Skamorina K. D. Kaplanov T. N. Obukhova I. V. Galtseva M. A. Rusinov S. M. Kulikov V. G. Savchenko |
| author_facet | E. N. Parovichnikova V. V. Troitskaya A. N. Sokolov Z. Kh. Akhmerzaeva L. A. Kuzmina L. P. Mendeleeva G. A. Klyasova S. K. Kravchenko Ye. O. Gribanova S. N. Bondarenko O. Yu. Baranova T. S. Kaporskaya T. V. Ryltsova A. S. Nizamutdinova T. P. Zagoskina Ye. Ye. Zinina O. S. Samoylova A. V. Klimovich Ye. A. Karyakina A. S. Yelufer’eva L. V. Gavrilova T. S. Konstantinova I. Yu. Toropova A. S. Pristupa N. A. Vopilina T. S. Tikunova O. P. Skamorina K. D. Kaplanov T. N. Obukhova I. V. Galtseva M. A. Rusinov S. M. Kulikov V. G. Savchenko |
| author_sort | E. N. Parovichnikova |
| collection | DOAJ |
| description | <p>An interim analysis of long-term treatment results for 202 patients with acute lymphoblastic leukemia (ALL), aged 15–60 years, received therapy according protocol ALL-2009 was shown. The basic principle of ALL-2009 was non-aggressive, but continued cytostatic exposure, as well as the reproducibility in a regional hematology centers. Long-term treatment results of ALL-2009 are 2 times higher than the previously obtained in adult ALL patients within the Russian clinical multicenter studies of adult ALL. The 5‑year overall survival of patients younger than 30 years was 73.6 %, relapse-free survival (RFS) – 71.5 %, compared with 52.7 % and 61.8 % in patients aged 30 years and older, respectively. In patients with B-precursor ALL with normal karyotype of blast cells significantly higher 5‑year RFS (82.1 %) compared to patients with abnormal karyotype (58.8 %) was registered. For T-ALL cytogenetic characteristics of blast cells had no prognostic significance. For patients with T-ALL important to perform autologous stem cell transplantation as a later consolidation, as this significantly reduce<br />relapse rate (from 33 to 0 %).</p> |
| first_indexed | 2024-04-10T18:35:35Z |
| format | Article |
| id | doaj.art-853110f3d74449d98b9b5eb6ad46716e |
| institution | Directory Open Access Journal |
| issn | 1818-8346 |
| language | Russian |
| last_indexed | 2024-04-10T18:35:35Z |
| publishDate | 2015-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-853110f3d74449d98b9b5eb6ad46716e2023-02-02T01:37:59ZrusABV-pressОнкогематология1818-83462015-01-0193615133Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL))E. N. Parovichnikova0V. V. Troitskaya1A. N. Sokolov2Z. Kh. Akhmerzaeva3L. A. Kuzmina4L. P. Mendeleeva5G. A. Klyasova6S. K. Kravchenko7Ye. O. Gribanova8S. N. Bondarenko9O. Yu. Baranova10T. S. Kaporskaya11T. V. Ryltsova12A. S. Nizamutdinova13T. P. Zagoskina14Ye. Ye. Zinina15O. S. Samoylova16A. V. Klimovich17Ye. A. Karyakina18A. S. Yelufer’eva19L. V. Gavrilova20T. S. Konstantinova21I. Yu. Toropova22A. S. Pristupa23N. A. Vopilina24T. S. Tikunova25O. P. Skamorina26K. D. Kaplanov27T. N. Obukhova28I. V. Galtseva29M. A. Rusinov30S. M. Kulikov31V. G. Savchenko32Hematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaN.N. Blokhin Russian Cancer Research Center, MoscowIrkutsk Regional HospitalTula Regional HospitalMunicipal Alexander Hospital, St.-PetersburgKirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological AgencySurgut Regional HospitalN.A. Semashko Regional Clinical Hospital, N. NovgorodCity Clinical Hospital ‡‚ 31, St..PetersburgCity Hospital № 15, St.‑PetersburgM.I. Kalinin Regional Clinical Hospital, SamaraMordovian Republican Clinical Hospital, SaranskRegional Hematology Center, Sverdlovsk Regional Clinical Hospital № 1, YekaterinburgRegional Clinical Hospital, YaroslavlRegional Clinical Hospital, RyazanV.D. Babenko Regional Clinical Hospital, TambovSt. Ioasafa Belgorod Regional HospitalCentral Clinical Military Hospital, Federal Security Service of Russia, MoscowRegional Clinical Oncology Dispensary № 1, VolgogradHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, MoscowHematologic Scientific Center, Ministry of Health of Russia, Moscow<p>An interim analysis of long-term treatment results for 202 patients with acute lymphoblastic leukemia (ALL), aged 15–60 years, received therapy according protocol ALL-2009 was shown. The basic principle of ALL-2009 was non-aggressive, but continued cytostatic exposure, as well as the reproducibility in a regional hematology centers. Long-term treatment results of ALL-2009 are 2 times higher than the previously obtained in adult ALL patients within the Russian clinical multicenter studies of adult ALL. The 5‑year overall survival of patients younger than 30 years was 73.6 %, relapse-free survival (RFS) – 71.5 %, compared with 52.7 % and 61.8 % in patients aged 30 years and older, respectively. In patients with B-precursor ALL with normal karyotype of blast cells significantly higher 5‑year RFS (82.1 %) compared to patients with abnormal karyotype (58.8 %) was registered. For T-ALL cytogenetic characteristics of blast cells had no prognostic significance. For patients with T-ALL important to perform autologous stem cell transplantation as a later consolidation, as this significantly reduce<br />relapse rate (from 33 to 0 %).</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/118acute lymphoblastic leukemia in adultschromosomal abnormalitiesautologous stem cell transplantation |
| spellingShingle | E. N. Parovichnikova V. V. Troitskaya A. N. Sokolov Z. Kh. Akhmerzaeva L. A. Kuzmina L. P. Mendeleeva G. A. Klyasova S. K. Kravchenko Ye. O. Gribanova S. N. Bondarenko O. Yu. Baranova T. S. Kaporskaya T. V. Ryltsova A. S. Nizamutdinova T. P. Zagoskina Ye. Ye. Zinina O. S. Samoylova A. V. Klimovich Ye. A. Karyakina A. S. Yelufer’eva L. V. Gavrilova T. S. Konstantinova I. Yu. Toropova A. S. Pristupa N. A. Vopilina T. S. Tikunova O. P. Skamorina K. D. Kaplanov T. N. Obukhova I. V. Galtseva M. A. Rusinov S. M. Kulikov V. G. Savchenko Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) Онкогематология acute lymphoblastic leukemia in adults chromosomal abnormalities autologous stem cell transplantation |
| title | Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) |
| title_full | Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) |
| title_fullStr | Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) |
| title_full_unstemmed | Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) |
| title_short | Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL)) |
| title_sort | interim results of the ph negative acute lymphoblastic leukemia treatment in adult patients results of russian research group of all treatment rall |
| topic | acute lymphoblastic leukemia in adults chromosomal abnormalities autologous stem cell transplantation |
| url | http://oncohematology.abvpress.ru/index.php/ongm/article/view/118 |
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