Vanadium Compounds with Antidiabetic Potential
Over the last four decades, vanadium compounds have been extensively studied as potential antidiabetic drugs. With the present review, we aim at presenting a general overview of the most promising compounds and the main results obtained with in vivo studies, reported from 1899–2023. The chemistry of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15675 |
| _version_ | 1797631869635788800 |
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| author | Luísa M. P. F. Amaral Tânia Moniz André M. N. Silva Maria Rangel |
| author_facet | Luísa M. P. F. Amaral Tânia Moniz André M. N. Silva Maria Rangel |
| author_sort | Luísa M. P. F. Amaral |
| collection | DOAJ |
| description | Over the last four decades, vanadium compounds have been extensively studied as potential antidiabetic drugs. With the present review, we aim at presenting a general overview of the most promising compounds and the main results obtained with in vivo studies, reported from 1899–2023. The chemistry of vanadium is explored, discussing the importance of the structure and biochemistry of vanadate and the impact of its similarity with phosphate on the antidiabetic effect. The spectroscopic characterization of vanadium compounds is discussed, particularly magnetic resonance methodologies, emphasizing its relevance for understanding species activity, speciation, and interaction with biological membranes. Finally, the most relevant studies regarding the use of vanadium compounds to treat diabetes are summarized, considering both animal models and human clinical trials. An overview of the main hypotheses explaining the biological activity of these compounds is presented, particularly the most accepted pathway involving vanadium interaction with phosphatase and kinase enzymes involved in the insulin signaling cascade. From our point of view, the major discoveries regarding the pharmacological action of this family of compounds are not yet fully understood. Thus, we still believe that vanadium presents the potential to help in metabolic control and the clinical management of diabetes, either as an insulin-like drug or as an insulin adjuvant. We look forward to the next forty years of research in this field, aiming to discover a vanadium compound with the desired therapeutic properties. |
| first_indexed | 2024-03-11T11:28:48Z |
| format | Article |
| id | doaj.art-8532695a8ac84f22834e86252847bec6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:28:48Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8532695a8ac84f22834e86252847bec62023-11-10T15:04:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211567510.3390/ijms242115675Vanadium Compounds with Antidiabetic PotentialLuísa M. P. F. Amaral0Tânia Moniz1André M. N. Silva2Maria Rangel3LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 40169-007 Porto, PortugalLAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 40169-007 Porto, PortugalLAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 40169-007 Porto, PortugalLAQV, REQUIMTE, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, PortugalOver the last four decades, vanadium compounds have been extensively studied as potential antidiabetic drugs. With the present review, we aim at presenting a general overview of the most promising compounds and the main results obtained with in vivo studies, reported from 1899–2023. The chemistry of vanadium is explored, discussing the importance of the structure and biochemistry of vanadate and the impact of its similarity with phosphate on the antidiabetic effect. The spectroscopic characterization of vanadium compounds is discussed, particularly magnetic resonance methodologies, emphasizing its relevance for understanding species activity, speciation, and interaction with biological membranes. Finally, the most relevant studies regarding the use of vanadium compounds to treat diabetes are summarized, considering both animal models and human clinical trials. An overview of the main hypotheses explaining the biological activity of these compounds is presented, particularly the most accepted pathway involving vanadium interaction with phosphatase and kinase enzymes involved in the insulin signaling cascade. From our point of view, the major discoveries regarding the pharmacological action of this family of compounds are not yet fully understood. Thus, we still believe that vanadium presents the potential to help in metabolic control and the clinical management of diabetes, either as an insulin-like drug or as an insulin adjuvant. We look forward to the next forty years of research in this field, aiming to discover a vanadium compound with the desired therapeutic properties.https://www.mdpi.com/1422-0067/24/21/15675antidiabetic drugschemical speciationinsulin signalingdiabetes mellitusmetallopharmaceuticalsvanadium |
| spellingShingle | Luísa M. P. F. Amaral Tânia Moniz André M. N. Silva Maria Rangel Vanadium Compounds with Antidiabetic Potential International Journal of Molecular Sciences antidiabetic drugs chemical speciation insulin signaling diabetes mellitus metallopharmaceuticals vanadium |
| title | Vanadium Compounds with Antidiabetic Potential |
| title_full | Vanadium Compounds with Antidiabetic Potential |
| title_fullStr | Vanadium Compounds with Antidiabetic Potential |
| title_full_unstemmed | Vanadium Compounds with Antidiabetic Potential |
| title_short | Vanadium Compounds with Antidiabetic Potential |
| title_sort | vanadium compounds with antidiabetic potential |
| topic | antidiabetic drugs chemical speciation insulin signaling diabetes mellitus metallopharmaceuticals vanadium |
| url | https://www.mdpi.com/1422-0067/24/21/15675 |
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