Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma
Introduction: Glioblastoma represents the most aggressive tumor of the brain with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two decades, many studie...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2022-01-01
|
| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/428497 |
| _version_ | 1797206523261222912 |
|---|---|
| author | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Anamarija Soldo Koruga Ksenija Marjanović Jasmina Rajc Ante Rotim Krešimir Rotim |
| author_facet | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Anamarija Soldo Koruga Ksenija Marjanović Jasmina Rajc Ante Rotim Krešimir Rotim |
| author_sort | Nenad Koruga |
| collection | DOAJ |
| description | Introduction: Glioblastoma represents the most aggressive tumor of the brain
with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of
neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two
decades, many studies were conducted with the aim of confirming viral influence in the development
of glioblastoma.
Methods: We conducted a retrospective study in a time period of five years using formalin-fixed
paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses:
CMV, EBV and HSV-1, using an automated staining system.
Results: Mean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted.
Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded
from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as
IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study.
Conclusion: According to our retrospective study and its results, we found no impact of neurotropic
viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider
range of viral detection methods. |
| first_indexed | 2024-04-24T09:08:22Z |
| format | Article |
| id | doaj.art-85359ff7bc9749d9b0a7a033242832ed |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:08:22Z |
| publishDate | 2022-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-85359ff7bc9749d9b0a7a033242832ed2024-04-15T18:21:45ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512022-01-0161.347648110.20471/acc.2022.61.03.12Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated GlioblastomaNenad Koruga0Tatjana Pekmezović1Ilijan Tomaš2Anamarija Soldo Koruga3Ksenija Marjanović4Jasmina Rajc5Ante Rotim6Krešimir Rotim7Department of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, CroatiaInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, SerbiaDepartment of Oncology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, CroatiaDepartment of Neurology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, CroatiaDepartment of Pathology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, CroatiaDepartment of Pathology, University Hospital Center Osijek, Croatia; Faculty of Medicine, University of J.J. Strossmayer Osijek, Osijek, CroatiaDepartment of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Faculty of Medicine, University of Zagreb, Zagreb, CroatiaIntroduction: Glioblastoma represents the most aggressive tumor of the brain with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two decades, many studies were conducted with the aim of confirming viral influence in the development of glioblastoma. Methods: We conducted a retrospective study in a time period of five years using formalin-fixed paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses: CMV, EBV and HSV-1, using an automated staining system. Results: Mean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted. Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study. Conclusion: According to our retrospective study and its results, we found no impact of neurotropic viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider range of viral detection methods.https://hrcak.srce.hr/file/428497GlioblastomaBrain NeoplasmsCytomegalovirusHerpes SimplexAntibodies |
| spellingShingle | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Anamarija Soldo Koruga Ksenija Marjanović Jasmina Rajc Ante Rotim Krešimir Rotim Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma Acta Clinica Croatica Glioblastoma Brain Neoplasms Cytomegalovirus Herpes Simplex Antibodies |
| title | Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma |
| title_full | Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma |
| title_fullStr | Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma |
| title_full_unstemmed | Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma |
| title_short | Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma |
| title_sort | impact of neurotropic viruses on survival of patients with surgically treated glioblastoma |
| topic | Glioblastoma Brain Neoplasms Cytomegalovirus Herpes Simplex Antibodies |
| url | https://hrcak.srce.hr/file/428497 |
| work_keys_str_mv | AT nenadkoruga impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT tatjanapekmezovic impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT ilijantomas impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT anamarijasoldokoruga impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT ksenijamarjanovic impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT jasminarajc impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT anterotim impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma AT kresimirrotim impactofneurotropicvirusesonsurvivalofpatientswithsurgicallytreatedglioblastoma |