Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism

Low progesterone level is always linked with pre-term birth. Therefore, maintaining of progesterone level is vital during pregnancy. Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of 20-alpha-hydroxy-progesterone and thus limits the bio...

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Bibliographic Details
Main Authors: Chenming Zeng, Difeng Zhu, Jun You, Xiaowu Dong, Bo Yang, Hong Zhu, Qiaojun He
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
liquiritin
AKR1C1
inhibitor
progesterone metabolism
pre-term birth prevention
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00833/full

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