Mechanism of MyD88S mediated signal termination

Mechanism of MyD88S mediated signal termination

Abstract Background A universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Receptor activation seeds MyD88 dependent formation of a signal amplifying supramolecular organizing center (SMOC...

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Main Authors: Katarzyna Pustelny, Katarzyna Kuska, Andrzej Gorecki, Bogdan Musielak, Ewelina Dobosz, Benedykt Wladyka, Joanna Koziel, Anna Czarna, Tad Holak, Grzegorz Dubin
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cell Communication and Signaling
Subjects:
MyD88
MyD88S
Toll-like receptor (TIR)
Interleukin-1 receptor (IL-1R)
Signaling
Innate immunity
Online Access:https://doi.org/10.1186/s12964-021-00811-1

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