Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility

Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility

Abstract Introduction Although the heritability of sporadic Alzheimer’s disease (AD) is estimated to be 60–80%, addressing the genetic contribution to AD risk still remains elusive. More specifically, it remains unclear whether genetic variants are able to affect neurodegenerative brain features tha...

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Main Authors: Jieun Seo, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Seong A. Shin, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Gijung Jung, Jong-Chan Park, Sun-Ho Han, Jayoung Byun, Inhee Mook-Jung, Dong Young Lee, Murim Choi, for the KBASE Research Group
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Targeted panel sequencing
Genetic association
Neuroimaging
In vivo AD pathologies
PET
Online Access:http://link.springer.com/article/10.1186/s13195-020-00722-2

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