The Role of Autophagy in Acute Myocardial Infarction
Acute myocardial infarction refers to a sudden death of cardiomyocytes, which leads to a large mortality worldwide. To attenuate acute myocardial infarction, strategies should be made to increase cardiomyocyte survival, improve postinfarcted cardiac function, and reverse the process of cardiac remod...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00551/full |
| _version_ | 1811276025487687680 |
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| author | Du Wu Kangfeng Zhang Pengfei Hu |
| author_facet | Du Wu Kangfeng Zhang Pengfei Hu |
| author_sort | Du Wu |
| collection | DOAJ |
| description | Acute myocardial infarction refers to a sudden death of cardiomyocytes, which leads to a large mortality worldwide. To attenuate acute myocardial infarction, strategies should be made to increase cardiomyocyte survival, improve postinfarcted cardiac function, and reverse the process of cardiac remodeling. Autophagy, a pivotal cellular response, has been widely studied and is known to be involved in various kinds of diseases. In the recent few years, the role of autophagy in diseases has been drawn increasing attention to by researchers. Here in this review, we mainly focus on the discussion of the effect of autophagy on the pathogenesis and progression of acute myocardial infarction under ischemic and ischemia/reperfusion injuries. Furthermore, several popular therapeutic agents and strategies taking advantage of autophagy will be described. |
| first_indexed | 2024-04-12T23:49:10Z |
| format | Article |
| id | doaj.art-853a81d0c26c4af38d0f5a922f28171a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T23:49:10Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-853a81d0c26c4af38d0f5a922f28171a2022-12-22T03:11:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-05-011010.3389/fphar.2019.00551450918The Role of Autophagy in Acute Myocardial InfarctionDu Wu0Kangfeng Zhang1Pengfei Hu2Department of Internal Medicine, The WuYun Mountain Sanatorium of Hangzhou, Hangzhou, ChinaDepartment of Internal Medicine, The WuYun Mountain Sanatorium of Hangzhou, Hangzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaAcute myocardial infarction refers to a sudden death of cardiomyocytes, which leads to a large mortality worldwide. To attenuate acute myocardial infarction, strategies should be made to increase cardiomyocyte survival, improve postinfarcted cardiac function, and reverse the process of cardiac remodeling. Autophagy, a pivotal cellular response, has been widely studied and is known to be involved in various kinds of diseases. In the recent few years, the role of autophagy in diseases has been drawn increasing attention to by researchers. Here in this review, we mainly focus on the discussion of the effect of autophagy on the pathogenesis and progression of acute myocardial infarction under ischemic and ischemia/reperfusion injuries. Furthermore, several popular therapeutic agents and strategies taking advantage of autophagy will be described.https://www.frontiersin.org/article/10.3389/fphar.2019.00551/fullacute myocardial infarctionautophagycardiomyocyteischemiareperfusion |
| spellingShingle | Du Wu Kangfeng Zhang Pengfei Hu The Role of Autophagy in Acute Myocardial Infarction Frontiers in Pharmacology acute myocardial infarction autophagy cardiomyocyte ischemia reperfusion |
| title | The Role of Autophagy in Acute Myocardial Infarction |
| title_full | The Role of Autophagy in Acute Myocardial Infarction |
| title_fullStr | The Role of Autophagy in Acute Myocardial Infarction |
| title_full_unstemmed | The Role of Autophagy in Acute Myocardial Infarction |
| title_short | The Role of Autophagy in Acute Myocardial Infarction |
| title_sort | role of autophagy in acute myocardial infarction |
| topic | acute myocardial infarction autophagy cardiomyocyte ischemia reperfusion |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00551/full |
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