Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy
Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weigh...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/8/1703 |
| _version_ | 1797442711575330816 |
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| author | Yubiao Cao Zhuowen Chen Liangliang Sun Yameng Lin Ye Yang Xiuming Cui Chengxiao Wang |
| author_facet | Yubiao Cao Zhuowen Chen Liangliang Sun Yameng Lin Ye Yang Xiuming Cui Chengxiao Wang |
| author_sort | Yubiao Cao |
| collection | DOAJ |
| description | Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS. |
| first_indexed | 2024-03-09T12:45:56Z |
| format | Article |
| id | doaj.art-853b9d87e8a340d886d9ae18af7b4ce6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:45:56Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-853b9d87e8a340d886d9ae18af7b4ce62023-11-30T22:11:58ZengMDPI AGPharmaceutics1999-49232022-08-01148170310.3390/pharmaceutics14081703Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for ImmunotherapyYubiao Cao0Zhuowen Chen1Liangliang Sun2Yameng Lin3Ye Yang4Xiuming Cui5Chengxiao Wang6School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaHerb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS.https://www.mdpi.com/1999-4923/14/8/1703herb polysaccharidesdrug delivery systemimmune regulationstructure modificationapplication |
| spellingShingle | Yubiao Cao Zhuowen Chen Liangliang Sun Yameng Lin Ye Yang Xiuming Cui Chengxiao Wang Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy Pharmaceutics herb polysaccharides drug delivery system immune regulation structure modification application |
| title | Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy |
| title_full | Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy |
| title_fullStr | Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy |
| title_full_unstemmed | Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy |
| title_short | Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy |
| title_sort | herb polysaccharide based drug delivery system fabrication properties and applications for immunotherapy |
| topic | herb polysaccharides drug delivery system immune regulation structure modification application |
| url | https://www.mdpi.com/1999-4923/14/8/1703 |
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