Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits
Background: Dairy sector is one of the leading in agricultural production in the world and the bovine herpesvirus 1 (BoHV-1) is an important pathogen that causes great losses in most production systems. Moreover, BoLA DRB3 immunological gene that presents different alleles related whit protection ag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2020-09-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | https://www.openveterinaryjournal.com/OVJ-2020-03-076%20J.P.A.%20Morales%20et%20al.pdf |
| _version_ | 1818364708196974592 |
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| author | Juan Pablo Arismendy Morales Albeiro López-Herrera Julián Echeverri Zuluaga |
| author_facet | Juan Pablo Arismendy Morales Albeiro López-Herrera Julián Echeverri Zuluaga |
| author_sort | Juan Pablo Arismendy Morales |
| collection | DOAJ |
| description | Background: Dairy sector is one of the leading in agricultural production in the world and the bovine herpesvirus 1 (BoHV-1) is an important pathogen that causes great losses in most production systems. Moreover, BoLA DRB3 immunological gene that presents different alleles related whit protection against many pathogens.
Methods: Serological diagnosis was made for determine BoHV-1 infection and through PCR-RFLP five hundred six Holstein cows from several municipalities of Antioquia were genotyped for BoLA DRB3.2 gene polymorphisms.
Results: Alleles 8, 16, 22 and 24 were the most common out of the 42 found. By indirect ELISA technique a prevalence of 58.7% of BoHV-1 infection in this population was diagnosed, and OR for found alleles were calculated by logistic regression; the only significant association was held for allele 37, showing that its effect confers susceptibility to infection. On the other hand, using generalized linear models, significant association between BoLA DRB3.2 gene and milk and fat yield in primiparous and services per conception in multiparous was found, being the most favorable alleles 11 and 28 in primiparous, and 22 and 28 in multiparous; 37 allele was unfavorable only in primiparous.
Conclusion: BoLA DRB3.2 gene polymorphisms have shown high variability and significant effects on Holstein cattle and their performance in production systems in Antioquia, both at sanitary or health and productive level. |
| first_indexed | 2024-12-13T22:08:40Z |
| format | Article |
| id | doaj.art-853be8c04fc44879b6994497bdb26cc8 |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-13T22:08:40Z |
| publishDate | 2020-09-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-853be8c04fc44879b6994497bdb26cc82022-12-21T23:29:45ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502020-09-01103331339http://dx.doi.org/10.4314/ovj.v10i3.12Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traitsJuan Pablo Arismendy Morales0https://orcid.org/0000-0002-0524-3162Albeiro López-Herrera1https://orcid.org/0000-0003-1444-3470Julián Echeverri Zuluaga2https://orcid.org/0000-0002-9613-0621Biodiversity and Molecular Genetics Research Group “BIOGEM”, Animal Production Department, Universidad Nacional de Colombia, Medellín Campus, Street 65 #59a-110, Medellín, ColombiaBiodiversity and Molecular Genetics Research Group “BIOGEM”, Animal Production Department, Universidad Nacional de Colombia, Medellín Campus, Street 65 #59a-110, Medellín, ColombiaBiodiversity and Molecular Genetics Research Group “BIOGEM”, Animal Production Department, Universidad Nacional de Colombia, Medellín Campus, Street 65 #59a-110, Medellín, ColombiaBackground: Dairy sector is one of the leading in agricultural production in the world and the bovine herpesvirus 1 (BoHV-1) is an important pathogen that causes great losses in most production systems. Moreover, BoLA DRB3 immunological gene that presents different alleles related whit protection against many pathogens. Methods: Serological diagnosis was made for determine BoHV-1 infection and through PCR-RFLP five hundred six Holstein cows from several municipalities of Antioquia were genotyped for BoLA DRB3.2 gene polymorphisms. Results: Alleles 8, 16, 22 and 24 were the most common out of the 42 found. By indirect ELISA technique a prevalence of 58.7% of BoHV-1 infection in this population was diagnosed, and OR for found alleles were calculated by logistic regression; the only significant association was held for allele 37, showing that its effect confers susceptibility to infection. On the other hand, using generalized linear models, significant association between BoLA DRB3.2 gene and milk and fat yield in primiparous and services per conception in multiparous was found, being the most favorable alleles 11 and 28 in primiparous, and 22 and 28 in multiparous; 37 allele was unfavorable only in primiparous. Conclusion: BoLA DRB3.2 gene polymorphisms have shown high variability and significant effects on Holstein cattle and their performance in production systems in Antioquia, both at sanitary or health and productive level.https://www.openveterinaryjournal.com/OVJ-2020-03-076%20J.P.A.%20Morales%20et%20al.pdfholsteinimmunityprevalenceproductionreproduction |
| spellingShingle | Juan Pablo Arismendy Morales Albeiro López-Herrera Julián Echeverri Zuluaga Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits Open Veterinary Journal holstein immunity prevalence production reproduction |
| title | Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits |
| title_full | Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits |
| title_fullStr | Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits |
| title_full_unstemmed | Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits |
| title_short | Association of BoLA DRB3 gene polymorphisms with BoHV-1 infection and zoothecnical traits |
| title_sort | association of bola drb3 gene polymorphisms with bohv 1 infection and zoothecnical traits |
| topic | holstein immunity prevalence production reproduction |
| url | https://www.openveterinaryjournal.com/OVJ-2020-03-076%20J.P.A.%20Morales%20et%20al.pdf |
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