LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity

Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial peptide, has recently been recognized as an endogenous blocker of growth hormone secretagogue receptor 1a (GHS-R1a). GHS-R1a, also known as ghrelin receptor, is a G protein-coupled receptor (GPCR) widely distr...

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Hlavní autoři: Xuehan Lu, Lili Huang, Zhengxiang Huang, Dandan Feng, Richard J. Clark, Chen Chen
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2021-08-01
Edice:Frontiers in Endocrinology
Témata:
On-line přístup:https://www.frontiersin.org/articles/10.3389/fendo.2021.717544/full