Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study
Antibiotics are frequently prescribed to patients with COVID-19. The aim was to determine the pattern of use of systemic antibiotics in a group of patients diagnosed with COVID-19 in Colombia between 2020–2022. This was a descriptive cross-sectional study designed to identify antibiotics prescriptio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/252 |
| _version_ | 1797622780679684096 |
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| author | Luis Fernando Valladales-Restrepo Ana Camila Delgado-Araujo Luisa Fernanda Echeverri-Martínez Verónica Sánchez-Ríos Jorge Enrique Machado-Alba |
| author_facet | Luis Fernando Valladales-Restrepo Ana Camila Delgado-Araujo Luisa Fernanda Echeverri-Martínez Verónica Sánchez-Ríos Jorge Enrique Machado-Alba |
| author_sort | Luis Fernando Valladales-Restrepo |
| collection | DOAJ |
| description | Antibiotics are frequently prescribed to patients with COVID-19. The aim was to determine the pattern of use of systemic antibiotics in a group of patients diagnosed with COVID-19 in Colombia between 2020–2022. This was a descriptive cross-sectional study designed to identify antibiotics prescription patterns for patients diagnosed with COVID-19 treated in eight clinics in Colombia. The AWaRe tool of the World Health Organization (WHO) was used to classify the antibiotics. A total of 10,916 patients were included. The median age was 57 years, and 56.4% were male. A total of 57.5% received antibiotics, especially ampicillin/sulbactam (58.8%) and clarithromycin (47.9%). Most of the antibiotics were classified as Watch (65.1%), followed by Access (32.6%) and Reserve (2.4%). Men (OR: 1.29; 95%CI: 1.17–1.43), older adults (OR: 1.67; 95%CI: 1.48–1.88), patients with dyspnea (OR: 1.26; 95%CI: 1.13–1.41), rheumatoid arthritis (OR: 1.94; 95%CI: 1.17–3.20), and high blood pressure at admission (OR: 1.45; 95%CI: 1.29–1.63), patients treated in-hospital (OR: 5.15; 95%CI: 4.59–5.77), patients admitted to the ICU (OR: 10.48; 95%CI: 8.82–12.45), patients treated with systemic glucocorticoids (OR: 3.60; 95%CI: 3.21–4.03) and vasopressors (OR: 2.10; 95%CI: 1.60–2.75), and patients who received invasive mechanical ventilation (OR: 2.37; 95%CI: 1.82–3.09) were more likely to receive a systemic antibiotic. Most of the patients diagnosed with COVID-19 received antibiotics, despite evidence showing that bacterial coinfection is rare. Antibiotics from the Watch group predominated, a practice that goes against WHO recommendations. |
| first_indexed | 2024-03-11T09:15:07Z |
| format | Article |
| id | doaj.art-853c77d7641a4d8cb6fbb5f399bc6e07 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:15:07Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-853c77d7641a4d8cb6fbb5f399bc6e072023-11-16T18:42:21ZengMDPI AGAntibiotics2079-63822023-01-0112225210.3390/antibiotics12020252Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional StudyLuis Fernando Valladales-Restrepo0Ana Camila Delgado-Araujo1Luisa Fernanda Echeverri-Martínez2Verónica Sánchez-Ríos3Jorge Enrique Machado-Alba4Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660002, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660002, ColombiaSemillero de Investigación en Farmacología Geriátrica, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira 660005, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660002, ColombiaGrupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660002, ColombiaAntibiotics are frequently prescribed to patients with COVID-19. The aim was to determine the pattern of use of systemic antibiotics in a group of patients diagnosed with COVID-19 in Colombia between 2020–2022. This was a descriptive cross-sectional study designed to identify antibiotics prescription patterns for patients diagnosed with COVID-19 treated in eight clinics in Colombia. The AWaRe tool of the World Health Organization (WHO) was used to classify the antibiotics. A total of 10,916 patients were included. The median age was 57 years, and 56.4% were male. A total of 57.5% received antibiotics, especially ampicillin/sulbactam (58.8%) and clarithromycin (47.9%). Most of the antibiotics were classified as Watch (65.1%), followed by Access (32.6%) and Reserve (2.4%). Men (OR: 1.29; 95%CI: 1.17–1.43), older adults (OR: 1.67; 95%CI: 1.48–1.88), patients with dyspnea (OR: 1.26; 95%CI: 1.13–1.41), rheumatoid arthritis (OR: 1.94; 95%CI: 1.17–3.20), and high blood pressure at admission (OR: 1.45; 95%CI: 1.29–1.63), patients treated in-hospital (OR: 5.15; 95%CI: 4.59–5.77), patients admitted to the ICU (OR: 10.48; 95%CI: 8.82–12.45), patients treated with systemic glucocorticoids (OR: 3.60; 95%CI: 3.21–4.03) and vasopressors (OR: 2.10; 95%CI: 1.60–2.75), and patients who received invasive mechanical ventilation (OR: 2.37; 95%CI: 1.82–3.09) were more likely to receive a systemic antibiotic. Most of the patients diagnosed with COVID-19 received antibiotics, despite evidence showing that bacterial coinfection is rare. Antibiotics from the Watch group predominated, a practice that goes against WHO recommendations.https://www.mdpi.com/2079-6382/12/2/252COVID-19SARS-CoV-2inappropriate prescribingantibacterial agentsintensive care unitsColombia |
| spellingShingle | Luis Fernando Valladales-Restrepo Ana Camila Delgado-Araujo Luisa Fernanda Echeverri-Martínez Verónica Sánchez-Ríos Jorge Enrique Machado-Alba Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study Antibiotics COVID-19 SARS-CoV-2 inappropriate prescribing antibacterial agents intensive care units Colombia |
| title | Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study |
| title_full | Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study |
| title_fullStr | Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study |
| title_full_unstemmed | Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study |
| title_short | Use of Systemic Antibiotics in Patients with COVID-19 in Colombia: A Cross-Sectional Study |
| title_sort | use of systemic antibiotics in patients with covid 19 in colombia a cross sectional study |
| topic | COVID-19 SARS-CoV-2 inappropriate prescribing antibacterial agents intensive care units Colombia |
| url | https://www.mdpi.com/2079-6382/12/2/252 |
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