A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma
Metastatic uterine tumors originating from extragenital cancers are a rare clinical occurrence. We report a case of metastatic uterine cancer derived from small-cell lung cancer (SCLC) that necessitated surgical treatment. The patient was a 59 y/o female who had undergone chemotherapy for stage IIIB...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2021-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2021/1809017 |
| _version_ | 1826998839426416640 |
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| author | Mariko Fujima Yoichi Kobayashi Momoe Watanabe Hiromi Shibuya Hironori Matsumoto Yoshiko Nishigaya Mai Momomura Shinya Yoshiike Kiyotaka Nagahama Junji Shibahara Atsushi Suzuki |
| author_facet | Mariko Fujima Yoichi Kobayashi Momoe Watanabe Hiromi Shibuya Hironori Matsumoto Yoshiko Nishigaya Mai Momomura Shinya Yoshiike Kiyotaka Nagahama Junji Shibahara Atsushi Suzuki |
| author_sort | Mariko Fujima |
| collection | DOAJ |
| description | Metastatic uterine tumors originating from extragenital cancers are a rare clinical occurrence. We report a case of metastatic uterine cancer derived from small-cell lung cancer (SCLC) that necessitated surgical treatment. The patient was a 59 y/o female who had undergone chemotherapy for stage IIIB SCLC. A 15 cm uterine tumor lesion was initially detected on CT scans. The patient had previously been diagnosed with uterine fibroids, but compared to the most recent CT scans taken one and a half months earlier, imaging diagnosis revealed a sudden increase in the size of the tumor when compared to the 8 cm myoma fibroid noted previously. Additional work-up with MRI scans revealed T2-enhanced images of a tumor that had almost completely invaded the myometrium; the tumor presented with marked diffusion-weighted enhancement, and a flow void was noted within the tumor. A differential diagnosis of uterine sarcoma was considered, but due to the lack of focal hemorrhage or necrosis findings on MRI imaging, the possibility of differential diagnosis of metastatic SCLC was also noted. As the patient was experiencing abdominal symptoms including abdominal distension and tenderness due the tumor, a simple hysterectomy and bilateral salpingo-oophorectomy were performed to palliate the symptoms. During the surgical procedures, intra-abdominal findings noted peritoneal dissemination while intraoperative cell cytology diagnosis of ascites revealed small-cell cancer. The final histopathological diagnosis likewise revealed metastatic small-cell cancer from the primary lung cancer. The clinical status of the lung cancer was evaluated as progressive disease (PD), and a change in chemotherapy regimen was necessitated. Further disease progression was noted on CT scans at 2 and a half months after surgery, and with gradual systemic disease progression, the patient died of disease at 3 months postsurgery. Initial evaluation of rapidly enlarging uterine tumors should include a differential diagnosis of uterine sarcoma; additionally, it is necessary to also consider the rare possibility of metastatic disease as in the present case with a clinical history of extragenital malignancy. |
| first_indexed | 2024-04-11T19:59:08Z |
| format | Article |
| id | doaj.art-853d2edd438c4c578bd30f217fd524fb |
| institution | Directory Open Access Journal |
| issn | 2090-6684 2090-6692 |
| language | English |
| last_indexed | 2025-02-18T10:20:36Z |
| publishDate | 2021-01-01 |
| publisher | Hindawi Limited |
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| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj.art-853d2edd438c4c578bd30f217fd524fb2024-11-02T05:31:29ZengHindawi LimitedCase Reports in Obstetrics and Gynecology2090-66842090-66922021-01-01202110.1155/2021/18090171809017A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine SarcomaMariko Fujima0Yoichi Kobayashi1Momoe Watanabe2Hiromi Shibuya3Hironori Matsumoto4Yoshiko Nishigaya5Mai Momomura6Shinya Yoshiike7Kiyotaka Nagahama8Junji Shibahara9Atsushi Suzuki10Department of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, JapanDepartment of Pathology, Kyorin University School of Medicine, JapanDepartment of Pathology, Kyorin University School of Medicine, JapanDepartment of Pathology, Kyorin University School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kosei Hospital, JapanMetastatic uterine tumors originating from extragenital cancers are a rare clinical occurrence. We report a case of metastatic uterine cancer derived from small-cell lung cancer (SCLC) that necessitated surgical treatment. The patient was a 59 y/o female who had undergone chemotherapy for stage IIIB SCLC. A 15 cm uterine tumor lesion was initially detected on CT scans. The patient had previously been diagnosed with uterine fibroids, but compared to the most recent CT scans taken one and a half months earlier, imaging diagnosis revealed a sudden increase in the size of the tumor when compared to the 8 cm myoma fibroid noted previously. Additional work-up with MRI scans revealed T2-enhanced images of a tumor that had almost completely invaded the myometrium; the tumor presented with marked diffusion-weighted enhancement, and a flow void was noted within the tumor. A differential diagnosis of uterine sarcoma was considered, but due to the lack of focal hemorrhage or necrosis findings on MRI imaging, the possibility of differential diagnosis of metastatic SCLC was also noted. As the patient was experiencing abdominal symptoms including abdominal distension and tenderness due the tumor, a simple hysterectomy and bilateral salpingo-oophorectomy were performed to palliate the symptoms. During the surgical procedures, intra-abdominal findings noted peritoneal dissemination while intraoperative cell cytology diagnosis of ascites revealed small-cell cancer. The final histopathological diagnosis likewise revealed metastatic small-cell cancer from the primary lung cancer. The clinical status of the lung cancer was evaluated as progressive disease (PD), and a change in chemotherapy regimen was necessitated. Further disease progression was noted on CT scans at 2 and a half months after surgery, and with gradual systemic disease progression, the patient died of disease at 3 months postsurgery. Initial evaluation of rapidly enlarging uterine tumors should include a differential diagnosis of uterine sarcoma; additionally, it is necessary to also consider the rare possibility of metastatic disease as in the present case with a clinical history of extragenital malignancy.http://dx.doi.org/10.1155/2021/1809017 |
| spellingShingle | Mariko Fujima Yoichi Kobayashi Momoe Watanabe Hiromi Shibuya Hironori Matsumoto Yoshiko Nishigaya Mai Momomura Shinya Yoshiike Kiyotaka Nagahama Junji Shibahara Atsushi Suzuki A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma Case Reports in Obstetrics and Gynecology |
| title | A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma |
| title_full | A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma |
| title_fullStr | A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma |
| title_full_unstemmed | A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma |
| title_short | A Case of Metastatic Uterine Tumor Originating from Small-Cell Lung Cancer (SCLC) Mimicking Uterine Sarcoma |
| title_sort | case of metastatic uterine tumor originating from small cell lung cancer sclc mimicking uterine sarcoma |
| url | http://dx.doi.org/10.1155/2021/1809017 |
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