ADAMTS Proteases: Importance in Animal Reproduction
Many reproductive physiological processes, such as folliculogenesis, ovulation, implantation, and fertilization, require the synthesis, remodeling, and degradation of the extracellular matrix (ECM). The <i>ADAMTS</i> (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/6/1181 |
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| author | Pamela Hernández-Delgado Monserrath Felix-Portillo José A. Martínez-Quintana |
| author_facet | Pamela Hernández-Delgado Monserrath Felix-Portillo José A. Martínez-Quintana |
| author_sort | Pamela Hernández-Delgado |
| collection | DOAJ |
| description | Many reproductive physiological processes, such as folliculogenesis, ovulation, implantation, and fertilization, require the synthesis, remodeling, and degradation of the extracellular matrix (ECM). The <i>ADAMTS</i> (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family genes code for key metalloproteinases in the remodeling process of different ECM. Several genes of this family encode for proteins with important functions in reproductive processes; in particular, <i>ADAMTS1</i>, 4, 5 and 9 are genes that are differentially expressed in cell types and the physiological stages of reproductive tissues. ADAMTS enzymes degrade proteoglycans in the ECM of the follicles so that the oocytes can be released and regulate follicle development during folliculogenesis, favoring the action of essential growth factors, such as FGF-2, FGF-7 and GDF-9. The transcriptional regulation of <i>ADAMTS1</i> and 9 in preovulatory follicles occurs because of the gonadotropin surge in preovulatory follicles, via the progesterone/progesterone receptor complex. In addition, in the case of ADAMTS1, pathways involving protein kinase A (PKA), extracellular signal regulated protein kinase (ERK1/2) and the epidermal growth factor receptor (EGFR) might contribute to ECM regulation. Different <i>Omic</i> studies indicate the importance of genes of the <i>ADAMTS</i> family from a reproductive aspect. <i>ADAMTS</i> genes could serve as biomarkers for genetic improvement and contribute to enhance fertility and animal reproduction; however, more research related to these genes, the synthesis of proteins encoded by these genes, and regulation in farm animals is needed. |
| first_indexed | 2024-03-11T02:25:30Z |
| format | Article |
| id | doaj.art-853f2bb5bbb54c56b9e39df8460574f1 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T02:25:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-853f2bb5bbb54c56b9e39df8460574f12023-11-18T10:33:56ZengMDPI AGGenes2073-44252023-05-01146118110.3390/genes14061181ADAMTS Proteases: Importance in Animal ReproductionPamela Hernández-Delgado0Monserrath Felix-Portillo1José A. Martínez-Quintana2Facultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua, Chihuahua 31453, MexicoFacultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua, Chihuahua 31453, MexicoFacultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua, Chihuahua 31453, MexicoMany reproductive physiological processes, such as folliculogenesis, ovulation, implantation, and fertilization, require the synthesis, remodeling, and degradation of the extracellular matrix (ECM). The <i>ADAMTS</i> (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family genes code for key metalloproteinases in the remodeling process of different ECM. Several genes of this family encode for proteins with important functions in reproductive processes; in particular, <i>ADAMTS1</i>, 4, 5 and 9 are genes that are differentially expressed in cell types and the physiological stages of reproductive tissues. ADAMTS enzymes degrade proteoglycans in the ECM of the follicles so that the oocytes can be released and regulate follicle development during folliculogenesis, favoring the action of essential growth factors, such as FGF-2, FGF-7 and GDF-9. The transcriptional regulation of <i>ADAMTS1</i> and 9 in preovulatory follicles occurs because of the gonadotropin surge in preovulatory follicles, via the progesterone/progesterone receptor complex. In addition, in the case of ADAMTS1, pathways involving protein kinase A (PKA), extracellular signal regulated protein kinase (ERK1/2) and the epidermal growth factor receptor (EGFR) might contribute to ECM regulation. Different <i>Omic</i> studies indicate the importance of genes of the <i>ADAMTS</i> family from a reproductive aspect. <i>ADAMTS</i> genes could serve as biomarkers for genetic improvement and contribute to enhance fertility and animal reproduction; however, more research related to these genes, the synthesis of proteins encoded by these genes, and regulation in farm animals is needed.https://www.mdpi.com/2073-4425/14/6/1181animal reproductionADAMTSextracellular matrixgenetic improvement |
| spellingShingle | Pamela Hernández-Delgado Monserrath Felix-Portillo José A. Martínez-Quintana ADAMTS Proteases: Importance in Animal Reproduction Genes animal reproduction ADAMTS extracellular matrix genetic improvement |
| title | ADAMTS Proteases: Importance in Animal Reproduction |
| title_full | ADAMTS Proteases: Importance in Animal Reproduction |
| title_fullStr | ADAMTS Proteases: Importance in Animal Reproduction |
| title_full_unstemmed | ADAMTS Proteases: Importance in Animal Reproduction |
| title_short | ADAMTS Proteases: Importance in Animal Reproduction |
| title_sort | adamts proteases importance in animal reproduction |
| topic | animal reproduction ADAMTS extracellular matrix genetic improvement |
| url | https://www.mdpi.com/2073-4425/14/6/1181 |
| work_keys_str_mv | AT pamelahernandezdelgado adamtsproteasesimportanceinanimalreproduction AT monserrathfelixportillo adamtsproteasesimportanceinanimalreproduction AT joseamartinezquintana adamtsproteasesimportanceinanimalreproduction |