Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study
Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food inta...
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| Format: | Article |
| Language: | English |
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Kirsehir Ahi Evran University
2023-12-01
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| Series: | Ahi Evran Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2833612 |
| _version_ | 1797374027998691328 |
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| author | Ahmet TÜRK Abdullah KARADAĞ Büşra ZENCİRCİ Yusuf ÖZAY Osman GÜLER |
| author_facet | Ahmet TÜRK Abdullah KARADAĞ Büşra ZENCİRCİ Yusuf ÖZAY Osman GÜLER |
| author_sort | Ahmet TÜRK |
| collection | DOAJ |
| description | Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food intake may reduce its synthesis. Kisspeptin plays a major role in reproductive hormones and its receptors are expressed in tissues with high metabolic activity, such as the liver. This study aims to investigate the effects of HFCS consumption on liver tissue and its relationship with Kisspeptin and Ghrelin levels.
Materials and Methods: Fourteen adult male Wistar albino rats, aged eight to ten weeks, were used in this study and divided into two groups; Control and HFCS (n=7). Tumor Necrosis Factor-alpha (TNF-α), Ghrelin, and Kisspeptin levels in the liver tissues of the rats were measured using an immunohistochemical method and subsequently analyzed through histoscoring.
Results: Our data revealed a significant increase in Kisspeptin, Caspase 3, and TNF-α levels and a decrease in Ghrelin levels in the HFCS group compared to the Control group.
Conclusion: In conclusion, our study demonstrates, for the first time, changes in liver Kisspeptin levels induced by a high fructose diet. Furthermore, the consumption of HFCS in food led to inflammatory activation, tissue damage, and reduced Ghrelin levels. |
| first_indexed | 2024-03-08T18:59:01Z |
| format | Article |
| id | doaj.art-853f33e3d0cd43f590de92f4382ffdee |
| institution | Directory Open Access Journal |
| issn | 2619-9203 |
| language | English |
| last_indexed | 2024-03-08T18:59:01Z |
| publishDate | 2023-12-01 |
| publisher | Kirsehir Ahi Evran University |
| record_format | Article |
| series | Ahi Evran Medical Journal |
| spelling | doaj.art-853f33e3d0cd43f590de92f4382ffdee2023-12-28T08:18:36ZengKirsehir Ahi Evran UniversityAhi Evran Medical Journal2619-92032023-12-017334635210.46332/aemj.1219449 Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological StudyAhmet TÜRK0https://orcid.org/0000-0003-0903-3522Abdullah KARADAĞ1https://orcid.org/0000-0003-3620-9589Büşra ZENCİRCİ2https://orcid.org/0000-0002-6015-3047Yusuf ÖZAY3https://orcid.org/0000-0003-3855-6197Osman GÜLER4https://orcid.org/0000-0001-8225-1505ADIYAMAN UNIVERSITYADIYAMAN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF PHYSIOLOGYADIYAMAN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF ANATOMYADIYAMAN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, MEDICAL DEPARTMENT OF BIOLOGYMUNZUR UNIVERSITY, PERTEK SAKİNE GENÇ VOCATIONAL SCHOOL, DEPARTMENT OF VETERINARY MEDICINEPurpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food intake may reduce its synthesis. Kisspeptin plays a major role in reproductive hormones and its receptors are expressed in tissues with high metabolic activity, such as the liver. This study aims to investigate the effects of HFCS consumption on liver tissue and its relationship with Kisspeptin and Ghrelin levels. Materials and Methods: Fourteen adult male Wistar albino rats, aged eight to ten weeks, were used in this study and divided into two groups; Control and HFCS (n=7). Tumor Necrosis Factor-alpha (TNF-α), Ghrelin, and Kisspeptin levels in the liver tissues of the rats were measured using an immunohistochemical method and subsequently analyzed through histoscoring. Results: Our data revealed a significant increase in Kisspeptin, Caspase 3, and TNF-α levels and a decrease in Ghrelin levels in the HFCS group compared to the Control group. Conclusion: In conclusion, our study demonstrates, for the first time, changes in liver Kisspeptin levels induced by a high fructose diet. Furthermore, the consumption of HFCS in food led to inflammatory activation, tissue damage, and reduced Ghrelin levels.https://dergipark.org.tr/tr/download/article-file/2833612apoptosisghrelinkisspeptinproinflammatory cytokines |
| spellingShingle | Ahmet TÜRK Abdullah KARADAĞ Büşra ZENCİRCİ Yusuf ÖZAY Osman GÜLER Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study Ahi Evran Medical Journal apoptosis ghrelin kisspeptin proinflammatory cytokines |
| title | Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study |
| title_full | Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study |
| title_fullStr | Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study |
| title_full_unstemmed | Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study |
| title_short | Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study |
| title_sort | investigation of the effects of ghrelin and kisspeptin levels in liver tissue of rats fed with high fructose diet a histological study |
| topic | apoptosis ghrelin kisspeptin proinflammatory cytokines |
| url | https://dergipark.org.tr/tr/download/article-file/2833612 |
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